Clinical application of ischemic preconditioning in the elderly

Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della-Morte, Gianluigi Galizia, Nicola Ferrara, Franco Rengo

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalDose-Response
Volume8
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Aging
  • Hormesis
  • Lifestyles
  • Preconditioning

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety
  • Public Health, Environmental and Occupational Health

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  • Cite this

    Abete, P., Cacciatore, F., Testa, G., Della-Morte, D., Galizia, G., Ferrara, N., & Rengo, F. (2010). Clinical application of ischemic preconditioning in the elderly. Dose-Response, 8(1), 34-40. https://doi.org/10.2203/dose-response.09-023.Abete