Clinical application of ischemic preconditioning in the elderly

Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della Morte, Gianluigi Galizia, Nicola Ferrara, Franco Rengo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalDose-Response
Volume8
Issue number1
DOIs
StatePublished - Mar 24 2010

Fingerprint

Ischemic Preconditioning
Myocardial Ischemia
Myocardial Ischemic Preconditioning
Nicorandil
Nutrition
Pharmaceutical Preparations
Adenosine
Life Style
Animals
Aging of materials
Research Personnel
Exercise
Diet
mitochondrial K(ATP) channel

Keywords

  • Aging
  • Hormesis
  • Lifestyles
  • Preconditioning

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety
  • Public Health, Environmental and Occupational Health

Cite this

Abete, P., Cacciatore, F., Testa, G., Della Morte, D., Galizia, G., Ferrara, N., & Rengo, F. (2010). Clinical application of ischemic preconditioning in the elderly. Dose-Response, 8(1), 34-40. https://doi.org/10.2203/dose-response.09-023.Abete

Clinical application of ischemic preconditioning in the elderly. / Abete, Pasquale; Cacciatore, Francesco; Testa, Gianluca; Della Morte, David; Galizia, Gianluigi; Ferrara, Nicola; Rengo, Franco.

In: Dose-Response, Vol. 8, No. 1, 24.03.2010, p. 34-40.

Research output: Contribution to journalArticle

Abete, P, Cacciatore, F, Testa, G, Della Morte, D, Galizia, G, Ferrara, N & Rengo, F 2010, 'Clinical application of ischemic preconditioning in the elderly', Dose-Response, vol. 8, no. 1, pp. 34-40. https://doi.org/10.2203/dose-response.09-023.Abete
Abete, Pasquale ; Cacciatore, Francesco ; Testa, Gianluca ; Della Morte, David ; Galizia, Gianluigi ; Ferrara, Nicola ; Rengo, Franco. / Clinical application of ischemic preconditioning in the elderly. In: Dose-Response. 2010 ; Vol. 8, No. 1. pp. 34-40.
@article{83661f2a28eb4c869852ca5e99ad9ca7,
title = "Clinical application of ischemic preconditioning in the elderly",
abstract = "A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical {"}hormetic mechanism{"} by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.",
keywords = "Aging, Hormesis, Lifestyles, Preconditioning",
author = "Pasquale Abete and Francesco Cacciatore and Gianluca Testa and {Della Morte}, David and Gianluigi Galizia and Nicola Ferrara and Franco Rengo",
year = "2010",
month = "3",
day = "24",
doi = "10.2203/dose-response.09-023.Abete",
language = "English",
volume = "8",
pages = "34--40",
journal = "Dose-Response",
issn = "1559-3258",
publisher = "International Dose-Response Society",
number = "1",

}

TY - JOUR

T1 - Clinical application of ischemic preconditioning in the elderly

AU - Abete, Pasquale

AU - Cacciatore, Francesco

AU - Testa, Gianluca

AU - Della Morte, David

AU - Galizia, Gianluigi

AU - Ferrara, Nicola

AU - Rengo, Franco

PY - 2010/3/24

Y1 - 2010/3/24

N2 - A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.

AB - A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.

KW - Aging

KW - Hormesis

KW - Lifestyles

KW - Preconditioning

UR - http://www.scopus.com/inward/record.url?scp=77949543954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949543954&partnerID=8YFLogxK

U2 - 10.2203/dose-response.09-023.Abete

DO - 10.2203/dose-response.09-023.Abete

M3 - Article

C2 - 20221286

AN - SCOPUS:77949543954

VL - 8

SP - 34

EP - 40

JO - Dose-Response

JF - Dose-Response

SN - 1559-3258

IS - 1

ER -