Clinical and pharmacological study of intrahepatic artery infusion of Thiotepa

L. G. Feun, G. Blyden, J. Yrizarry, M. Dorvil, S. Waldman, P. Benedetto, E. Donnelly, J. Curtas, M. George, N. Savaraj

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Twenty patients with primary or metastatic liver cancer were treated on a clinical and pharmacological study with intrahepatic artery infusion of Thiotepa. Toxicity was tolerable and included nausea and fatigue. Uncommon side effects were myelosuppression, abdominal pain and anemia. One patient with gallbladder cancer had a partial response for 11 (+) months. Recommended dose of Thiotepa for future Phase II clinical trials is 1.0 mg/kg. Pharmacokinetics of intrahepatic Thiotepa revealed an extraction ratio similar to that reported for cisplatin. The data suggest increased hepatic clearance for Thiotepa either by binding or metabolism.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalCancer Biotherapy
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

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