Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: A preliminary study

Carlos J. Bidot, Lawrence L. Horstman, Wenche Jy, Joaquin J Jimenez, Carlos Bidot, Yeon Ahn, J. Steven Steven, Eduardo Gonzalez-Toledo, Roger E. Kelley, Alireza Minagar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: The presence of antiphospholipid antibodies (APLA) in multiple sclerosis (MS) patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. Methods: A consecutive cohort of 24 subjects with relapsing-remitting (RR) MS were studied of whom 7 were in remission (Rem) and 17 in exacerbation (Exc). All subjects were examined and underwent MRI of brain. Patients' plasma was tested by standard ELISA for the presence of both IgM and IgG antibodies using a panel of 6 targets: cardiolipin (CL), β2 glycoprotein I (β2GPI), Factor VII/VIIa (FVIIa), phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE). Results: In exacerbation up to 80% of MS subjects had elevated titers of IgM antibodies directed against the above antigens. However, in remission, less than half of MS patients had elevated titers of IgM antibodies against one or more of the above antigens. This difference was significant, p < 0.01, for all 6 target antigens. Interestingly, none of the MS patients had elevated plasma titers of IgG against any of the target antigens tested. Correlation analysis between MRI enhancing lesions and plasma levels of APLA revealed high correlation for aPC, aPS and aFVIIa (p ≤ 0.0065), a trend for aPE and aCL (p = 0.056), and no correlation for aβ2GP1. The strongest correlation was for aFVIIa, p = 0.0002. Conclusion: The findings of this preliminary study show that increased APLA IgM is associated with exacerbations of MS. Currently, the significance of this association in pathogenesis of MS remains unknown. However, systematic longitudinal studies to measure APLA in larger cohorts of patients with relapsing-remitting MS, particularly before and after treatment with immunomodulatory agents, are needed to confirm these preliminary findings.

Original languageEnglish
Article number36
JournalBMC Neurology
Volume7
DOIs
StatePublished - Oct 18 2007

Fingerprint

Antiphospholipid Antibodies
Neuroimaging
Multiple Sclerosis
Immunoglobulin M
Antigens
Relapsing-Remitting Multiple Sclerosis
Antibodies
Immunoglobulin G
Factor VIIa
Factor VII
Cardiolipins
Phosphatidylserines
Phosphatidylcholines
Longitudinal Studies
Glycoproteins
Enzyme-Linked Immunosorbent Assay
Brain

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis : A preliminary study. / Bidot, Carlos J.; Horstman, Lawrence L.; Jy, Wenche; Jimenez, Joaquin J; Bidot, Carlos; Ahn, Yeon; Steven, J. Steven; Gonzalez-Toledo, Eduardo; Kelley, Roger E.; Minagar, Alireza.

In: BMC Neurology, Vol. 7, 36, 18.10.2007.

Research output: Contribution to journalArticle

Bidot, CJ, Horstman, LL, Jy, W, Jimenez, JJ, Bidot, C, Ahn, Y, Steven, JS, Gonzalez-Toledo, E, Kelley, RE & Minagar, A 2007, 'Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: A preliminary study', BMC Neurology, vol. 7, 36. https://doi.org/10.1186/1471-2377-7-36
Bidot, Carlos J. ; Horstman, Lawrence L. ; Jy, Wenche ; Jimenez, Joaquin J ; Bidot, Carlos ; Ahn, Yeon ; Steven, J. Steven ; Gonzalez-Toledo, Eduardo ; Kelley, Roger E. ; Minagar, Alireza. / Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis : A preliminary study. In: BMC Neurology. 2007 ; Vol. 7.
@article{67fa594fdd8746478a83185df849ab0c,
title = "Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: A preliminary study",
abstract = "Background: The presence of antiphospholipid antibodies (APLA) in multiple sclerosis (MS) patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. Methods: A consecutive cohort of 24 subjects with relapsing-remitting (RR) MS were studied of whom 7 were in remission (Rem) and 17 in exacerbation (Exc). All subjects were examined and underwent MRI of brain. Patients' plasma was tested by standard ELISA for the presence of both IgM and IgG antibodies using a panel of 6 targets: cardiolipin (CL), β2 glycoprotein I (β2GPI), Factor VII/VIIa (FVIIa), phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE). Results: In exacerbation up to 80{\%} of MS subjects had elevated titers of IgM antibodies directed against the above antigens. However, in remission, less than half of MS patients had elevated titers of IgM antibodies against one or more of the above antigens. This difference was significant, p < 0.01, for all 6 target antigens. Interestingly, none of the MS patients had elevated plasma titers of IgG against any of the target antigens tested. Correlation analysis between MRI enhancing lesions and plasma levels of APLA revealed high correlation for aPC, aPS and aFVIIa (p ≤ 0.0065), a trend for aPE and aCL (p = 0.056), and no correlation for aβ2GP1. The strongest correlation was for aFVIIa, p = 0.0002. Conclusion: The findings of this preliminary study show that increased APLA IgM is associated with exacerbations of MS. Currently, the significance of this association in pathogenesis of MS remains unknown. However, systematic longitudinal studies to measure APLA in larger cohorts of patients with relapsing-remitting MS, particularly before and after treatment with immunomodulatory agents, are needed to confirm these preliminary findings.",
author = "Bidot, {Carlos J.} and Horstman, {Lawrence L.} and Wenche Jy and Jimenez, {Joaquin J} and Carlos Bidot and Yeon Ahn and Steven, {J. Steven} and Eduardo Gonzalez-Toledo and Kelley, {Roger E.} and Alireza Minagar",
year = "2007",
month = "10",
day = "18",
doi = "10.1186/1471-2377-7-36",
language = "English",
volume = "7",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis

T2 - A preliminary study

AU - Bidot, Carlos J.

AU - Horstman, Lawrence L.

AU - Jy, Wenche

AU - Jimenez, Joaquin J

AU - Bidot, Carlos

AU - Ahn, Yeon

AU - Steven, J. Steven

AU - Gonzalez-Toledo, Eduardo

AU - Kelley, Roger E.

AU - Minagar, Alireza

PY - 2007/10/18

Y1 - 2007/10/18

N2 - Background: The presence of antiphospholipid antibodies (APLA) in multiple sclerosis (MS) patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. Methods: A consecutive cohort of 24 subjects with relapsing-remitting (RR) MS were studied of whom 7 were in remission (Rem) and 17 in exacerbation (Exc). All subjects were examined and underwent MRI of brain. Patients' plasma was tested by standard ELISA for the presence of both IgM and IgG antibodies using a panel of 6 targets: cardiolipin (CL), β2 glycoprotein I (β2GPI), Factor VII/VIIa (FVIIa), phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE). Results: In exacerbation up to 80% of MS subjects had elevated titers of IgM antibodies directed against the above antigens. However, in remission, less than half of MS patients had elevated titers of IgM antibodies against one or more of the above antigens. This difference was significant, p < 0.01, for all 6 target antigens. Interestingly, none of the MS patients had elevated plasma titers of IgG against any of the target antigens tested. Correlation analysis between MRI enhancing lesions and plasma levels of APLA revealed high correlation for aPC, aPS and aFVIIa (p ≤ 0.0065), a trend for aPE and aCL (p = 0.056), and no correlation for aβ2GP1. The strongest correlation was for aFVIIa, p = 0.0002. Conclusion: The findings of this preliminary study show that increased APLA IgM is associated with exacerbations of MS. Currently, the significance of this association in pathogenesis of MS remains unknown. However, systematic longitudinal studies to measure APLA in larger cohorts of patients with relapsing-remitting MS, particularly before and after treatment with immunomodulatory agents, are needed to confirm these preliminary findings.

AB - Background: The presence of antiphospholipid antibodies (APLA) in multiple sclerosis (MS) patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. Methods: A consecutive cohort of 24 subjects with relapsing-remitting (RR) MS were studied of whom 7 were in remission (Rem) and 17 in exacerbation (Exc). All subjects were examined and underwent MRI of brain. Patients' plasma was tested by standard ELISA for the presence of both IgM and IgG antibodies using a panel of 6 targets: cardiolipin (CL), β2 glycoprotein I (β2GPI), Factor VII/VIIa (FVIIa), phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE). Results: In exacerbation up to 80% of MS subjects had elevated titers of IgM antibodies directed against the above antigens. However, in remission, less than half of MS patients had elevated titers of IgM antibodies against one or more of the above antigens. This difference was significant, p < 0.01, for all 6 target antigens. Interestingly, none of the MS patients had elevated plasma titers of IgG against any of the target antigens tested. Correlation analysis between MRI enhancing lesions and plasma levels of APLA revealed high correlation for aPC, aPS and aFVIIa (p ≤ 0.0065), a trend for aPE and aCL (p = 0.056), and no correlation for aβ2GP1. The strongest correlation was for aFVIIa, p = 0.0002. Conclusion: The findings of this preliminary study show that increased APLA IgM is associated with exacerbations of MS. Currently, the significance of this association in pathogenesis of MS remains unknown. However, systematic longitudinal studies to measure APLA in larger cohorts of patients with relapsing-remitting MS, particularly before and after treatment with immunomodulatory agents, are needed to confirm these preliminary findings.

UR - http://www.scopus.com/inward/record.url?scp=38849123295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38849123295&partnerID=8YFLogxK

U2 - 10.1186/1471-2377-7-36

DO - 10.1186/1471-2377-7-36

M3 - Article

C2 - 17945023

AN - SCOPUS:38849123295

VL - 7

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

M1 - 36

ER -