Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a midwestern US Caucasian population

Marcos E. Maldonado, Magdalena Perez, Judith Pignac-Kobinger, Emily Triana Marx, Elaine Tozman, Eric L Greidinger, Robert W. Hoffman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective. A cross-sectional study of mixed connective tissue disease (MCTD) was performed to determine if there were identifiable differences in the clinical expression of MCTD associated with race or ethnicity. Methods. Miami, Florida, and Midwestern US (Missouri) Caucasian MCTD cohorts were studied. Clinical and laboratory features of the 2 MCTD cohorts were compared. A concurrently collected cohort of Sm-positive patients with systemic lupus erythematosus (SLE) was studied as a control. Disease activity and severity and functional status were measured. CD4+CD25high-expressing T-regulatory cells were enumerated and serum soluble L selectin was measured as biomarkers of disease activity. Results. The Miami and Missouri Caucasian MCTD groups, while differing from the SLE group, were largely similar; however, gastroesophageal reflux, sclerodactyly, and malar rash were significantly more frequent in the Missouri MCTD group and alopecia was more frequent in the Miami MCTD group. Significant clinical and laboratory differences were found between the Miami MCTD and Miami SLE groups despite similar disease duration, activity, severity and functional status. Raynaud's phenomenon (RP), hand swelling, synovitis, myositis, and sclerodactyly were all significantly more common in RNP-positive MCTD versus Sm-positive SLE subjects. Conclusion. Ethnic differences were observed in the frequency of end-organ involvement in the Miami MCTD versus the Missouri Caucasian MCTD groups. Clinical and laboratory features of all MCTD groups were clearly different from the SLE group, despite similar disease activity, disease severity, and functional status. Disease activity measures appeared to behave similarly as valid measures of disease activity in SLE and MCTD.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalJournal of Rheumatology
Volume35
Issue number3
StatePublished - Mar 1 2008
Externally publishedYes

Fingerprint

Mixed Connective Tissue Disease
Population
Systemic Lupus Erythematosus
L-Selectin
Raynaud Disease
Myositis
Synovitis
Alopecia
Regulatory T-Lymphocytes
Gastroesophageal Reflux
Exanthema

Keywords

  • Hispanic
  • L-selectin
  • Mixed connective tissue disease
  • Systemic lupus erythematosus
  • T-regulatory cells

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a midwestern US Caucasian population. / Maldonado, Marcos E.; Perez, Magdalena; Pignac-Kobinger, Judith; Marx, Emily Triana; Tozman, Elaine; Greidinger, Eric L; Hoffman, Robert W.

In: Journal of Rheumatology, Vol. 35, No. 3, 01.03.2008, p. 429-437.

Research output: Contribution to journalArticle

Maldonado, Marcos E. ; Perez, Magdalena ; Pignac-Kobinger, Judith ; Marx, Emily Triana ; Tozman, Elaine ; Greidinger, Eric L ; Hoffman, Robert W. / Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a midwestern US Caucasian population. In: Journal of Rheumatology. 2008 ; Vol. 35, No. 3. pp. 429-437.
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AU - Greidinger, Eric L

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