Clinical and immunologic effects of autologous lymph node cell transplant in chronic fatigue syndrome

N. G. Klimas, R. Patarca-Montero, K. Maher, M. Smith, O. Bathe, M. A. Fletcher

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

An open labeled, phase 1, safety and feasibility study using lymph node extraction, ex vivo lymph node cell expansion, followed by autologous cell reinfusion was evaluated as a potential immunomodulatory treatment strategy in patients with chronic fatigue syndrome (CFS). The experimental therapy utilized the cells of the lymph node, activated and grown in culture with defined media, interleukin-2 (IL-2) and anti-CD3 to activate and enhance cellular immunological functions. This procedure was designed to change the cytokine pattern of the lymph node lymphocytes to favor expression of T-helper (Th)1-type over Th2-type cytokines. The mixed population of ex vivo immune-enhanced cells were reinfused into the donor, who was carefully monitored for adverse events and possible clinical benefit. There were no adverse events. There were significant improvements in clinical status in association with a significant decrease in Th2-type cytokine production.

Original languageEnglish (US)
Pages (from-to)39-55
Number of pages17
JournalJournal Of Chronic Fatigue Syndrome
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Autologous lymph node cell transplant
  • Chronic fatigue syndrome
  • Cognitive difficulties
  • Immune activation
  • Natural killer cells
  • T-helper type 1 and type 2 cytokines

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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