Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis

Michelle P. Winn, Peter J. Conlon, Kelvin L. Lynn, David N. Howell, Deborah A. Gross, Allison R. Rogala, Anne H. Smith, Felicia L. Graham, MaryLou Bembe, L. Daryl Quarles, Margaret A Pericak-Vance, Jeffery M Vance

Research output: Contribution to journalArticle

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Abstract

Background. Familial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic basis of these hereditary forms of FSGS is unknown. One recent study of a kindred from Oklahoma with an autosomal dominant form of FSGS linked this disease to a region of chromosome 19q. In addition, polymorphisms in a gene in this region on chromosome 19q13 have been linked to congenital nephrotic syndrome of the Finnish type. We have ascertained and characterized a large family with autosomal dominant FFSGS (Duke 6530). Methods. Families were compared for clinical and genetic heterogeneity. To test for linkage of our family to this portion of chromosome 19, genomic DNA was isolated from 102 family members, and polymerase chain reaction was performed using eight microsatellite markers that spanned the area of interest on chromosome 19. Data were evaluated using two-point linkage analysis, multipoint analysis, and an admixture test. Results. Linkage was excluded at a distance of ±5 to 10 CM for all markers tested with two-point log10 of the odds of linkage (LOD) scores and from an approximate 60 CM interval in this area of chromosome 19q via multipoint analysis. Conclusions. FSGS has been called the 'final common pathway' of glomerular injury, as it is a frequent pathological manifestation with diverse etiologies. This diversity likely correlates with the genetic heterogeneity that we have established. Thus, our data demonstrate that there are at least two genes responsible for this disease, and there is genetic as well as clinical heterogeneity in autosomal dominant FSGS.

Original languageEnglish
Pages (from-to)1241-1246
Number of pages6
JournalKidney International
Volume55
Issue number4
DOIs
StatePublished - Apr 14 1999
Externally publishedYes

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Focal Segmental Glomerulosclerosis
Genetic Heterogeneity
Chromosomes, Human, Pair 19
Chromosomes
Inheritance Patterns
Inborn Genetic Diseases
Microsatellite Repeats
Genes
Polymerase Chain Reaction
DNA
Wounds and Injuries

Keywords

  • Familial nephropathy
  • Glomerular sclerosis
  • Heredity
  • Progressive renal disease
  • Tuft collapse

ASJC Scopus subject areas

  • Nephrology

Cite this

Winn, M. P., Conlon, P. J., Lynn, K. L., Howell, D. N., Gross, D. A., Rogala, A. R., ... Vance, J. M. (1999). Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. Kidney International, 55(4), 1241-1246. https://doi.org/10.1046/j.1523-1755.1999.00384.x

Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. / Winn, Michelle P.; Conlon, Peter J.; Lynn, Kelvin L.; Howell, David N.; Gross, Deborah A.; Rogala, Allison R.; Smith, Anne H.; Graham, Felicia L.; Bembe, MaryLou; Quarles, L. Daryl; Pericak-Vance, Margaret A; Vance, Jeffery M.

In: Kidney International, Vol. 55, No. 4, 14.04.1999, p. 1241-1246.

Research output: Contribution to journalArticle

Winn, MP, Conlon, PJ, Lynn, KL, Howell, DN, Gross, DA, Rogala, AR, Smith, AH, Graham, FL, Bembe, M, Quarles, LD, Pericak-Vance, MA & Vance, JM 1999, 'Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis', Kidney International, vol. 55, no. 4, pp. 1241-1246. https://doi.org/10.1046/j.1523-1755.1999.00384.x
Winn MP, Conlon PJ, Lynn KL, Howell DN, Gross DA, Rogala AR et al. Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. Kidney International. 1999 Apr 14;55(4):1241-1246. https://doi.org/10.1046/j.1523-1755.1999.00384.x
Winn, Michelle P. ; Conlon, Peter J. ; Lynn, Kelvin L. ; Howell, David N. ; Gross, Deborah A. ; Rogala, Allison R. ; Smith, Anne H. ; Graham, Felicia L. ; Bembe, MaryLou ; Quarles, L. Daryl ; Pericak-Vance, Margaret A ; Vance, Jeffery M. / Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. In: Kidney International. 1999 ; Vol. 55, No. 4. pp. 1241-1246.
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abstract = "Background. Familial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic basis of these hereditary forms of FSGS is unknown. One recent study of a kindred from Oklahoma with an autosomal dominant form of FSGS linked this disease to a region of chromosome 19q. In addition, polymorphisms in a gene in this region on chromosome 19q13 have been linked to congenital nephrotic syndrome of the Finnish type. We have ascertained and characterized a large family with autosomal dominant FFSGS (Duke 6530). Methods. Families were compared for clinical and genetic heterogeneity. To test for linkage of our family to this portion of chromosome 19, genomic DNA was isolated from 102 family members, and polymerase chain reaction was performed using eight microsatellite markers that spanned the area of interest on chromosome 19. Data were evaluated using two-point linkage analysis, multipoint analysis, and an admixture test. Results. Linkage was excluded at a distance of ±5 to 10 CM for all markers tested with two-point log10 of the odds of linkage (LOD) scores and from an approximate 60 CM interval in this area of chromosome 19q via multipoint analysis. Conclusions. FSGS has been called the 'final common pathway' of glomerular injury, as it is a frequent pathological manifestation with diverse etiologies. This diversity likely correlates with the genetic heterogeneity that we have established. Thus, our data demonstrate that there are at least two genes responsible for this disease, and there is genetic as well as clinical heterogeneity in autosomal dominant FSGS.",
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AU - Winn, Michelle P.

AU - Conlon, Peter J.

AU - Lynn, Kelvin L.

AU - Howell, David N.

AU - Gross, Deborah A.

AU - Rogala, Allison R.

AU - Smith, Anne H.

AU - Graham, Felicia L.

AU - Bembe, MaryLou

AU - Quarles, L. Daryl

AU - Pericak-Vance, Margaret A

AU - Vance, Jeffery M

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N2 - Background. Familial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic basis of these hereditary forms of FSGS is unknown. One recent study of a kindred from Oklahoma with an autosomal dominant form of FSGS linked this disease to a region of chromosome 19q. In addition, polymorphisms in a gene in this region on chromosome 19q13 have been linked to congenital nephrotic syndrome of the Finnish type. We have ascertained and characterized a large family with autosomal dominant FFSGS (Duke 6530). Methods. Families were compared for clinical and genetic heterogeneity. To test for linkage of our family to this portion of chromosome 19, genomic DNA was isolated from 102 family members, and polymerase chain reaction was performed using eight microsatellite markers that spanned the area of interest on chromosome 19. Data were evaluated using two-point linkage analysis, multipoint analysis, and an admixture test. Results. Linkage was excluded at a distance of ±5 to 10 CM for all markers tested with two-point log10 of the odds of linkage (LOD) scores and from an approximate 60 CM interval in this area of chromosome 19q via multipoint analysis. Conclusions. FSGS has been called the 'final common pathway' of glomerular injury, as it is a frequent pathological manifestation with diverse etiologies. This diversity likely correlates with the genetic heterogeneity that we have established. Thus, our data demonstrate that there are at least two genes responsible for this disease, and there is genetic as well as clinical heterogeneity in autosomal dominant FSGS.

AB - Background. Familial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic basis of these hereditary forms of FSGS is unknown. One recent study of a kindred from Oklahoma with an autosomal dominant form of FSGS linked this disease to a region of chromosome 19q. In addition, polymorphisms in a gene in this region on chromosome 19q13 have been linked to congenital nephrotic syndrome of the Finnish type. We have ascertained and characterized a large family with autosomal dominant FFSGS (Duke 6530). Methods. Families were compared for clinical and genetic heterogeneity. To test for linkage of our family to this portion of chromosome 19, genomic DNA was isolated from 102 family members, and polymerase chain reaction was performed using eight microsatellite markers that spanned the area of interest on chromosome 19. Data were evaluated using two-point linkage analysis, multipoint analysis, and an admixture test. Results. Linkage was excluded at a distance of ±5 to 10 CM for all markers tested with two-point log10 of the odds of linkage (LOD) scores and from an approximate 60 CM interval in this area of chromosome 19q via multipoint analysis. Conclusions. FSGS has been called the 'final common pathway' of glomerular injury, as it is a frequent pathological manifestation with diverse etiologies. This diversity likely correlates with the genetic heterogeneity that we have established. Thus, our data demonstrate that there are at least two genes responsible for this disease, and there is genetic as well as clinical heterogeneity in autosomal dominant FSGS.

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KW - Tuft collapse

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