Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group

Riad Salem, Siddharth A. Padia, Marnix Lam, Jon Bell, Carlo Chiesa, Kirk Fowers, Bonnie Hamilton, Joseph Herman, S. Cheenu Kappadath, Thomas Leung, Lorraine Portelance, Daniel Sze, Etienne Garin

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The TheraSphere Global Dosimetry Steering Committee was formed in 2017 by BTG International to review existing data and address gaps in knowledge related to dosimetry. This committee is comprised of health care providers with diverse areas of expertise and perspectives on radiation dosimetry. The goal of these recommendations is to optimize glass microspheres radiation therapy for hepatocellular carcinoma while accounting for variables including disease presentation, tumour vascularity, liver function, and curative/palliative intent. The recommendations aim to unify glass microsphere users behind standardized dosimetry methodology that is simple, reproducible and supported by clinical data, with the overarching goal of improving clinical outcomes and advancing the knowledge of dosimetry.

Original languageEnglish (US)
Pages (from-to)1695-1704
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume46
Issue number8
DOIs
StatePublished - Jul 1 2019

Keywords

  • Hepatocellular carcinoma
  • Liver cancer
  • Radioembolization
  • Yttrium-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Salem, R., Padia, S. A., Lam, M., Bell, J., Chiesa, C., Fowers, K., Hamilton, B., Herman, J., Kappadath, S. C., Leung, T., Portelance, L., Sze, D., & Garin, E. (2019). Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group. European Journal of Nuclear Medicine and Molecular Imaging, 46(8), 1695-1704. https://doi.org/10.1007/s00259-019-04340-5