Cleft lip and palate: No evidence of linkage to transforming growth factor alpha

J. T. Hecht; Y. Wang; S. H. Blanton; V. V. Michels; S. P. Daiger

Cleft lip and palate: No evidence of linkage to transforming growth factor alpha

J. T. Hecht, Y. Wang, S. H. Blanton, V. V. Michels, S. P. Daiger

Hussman Institute for Human Genomics

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.

Original language	English (US)
Pages (from-to)	682-686
Number of pages	5
Journal	American journal of human genetics
Volume	49
Issue number	3
State	Published - 1991

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Cleft lip and palate: No evidence of linkage to transforming growth factor alpha",

abstract = "Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.",

author = "Hecht, {J. T.} and Y. Wang and Blanton, {S. H.} and Michels, {V. V.} and Daiger, {S. P.}",

year = "1991",

language = "English (US)",

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pages = "682--686",

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T2 - No evidence of linkage to transforming growth factor alpha

AU - Hecht, J. T.

AU - Wang, Y.

AU - Blanton, S. H.

AU - Michels, V. V.

AU - Daiger, S. P.

PY - 1991

Y1 - 1991

N2 - Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.

AB - Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.

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