Abstract
Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.
| Original language | English |
|---|---|
| Pages (from-to) | 682-686 |
| Number of pages | 5 |
| Journal | American Journal of Human Genetics |
| Volume | 49 |
| Issue number | 3 |
| State | Published - Sep 1 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Cleft lip and palate : No evidence of linkage to transforming growth factor alpha. / Hecht, Jacqueline T.; Wang, Taping; Blanton, Susan H; Michels, Virginia V.; Daiger, Stephen P.
In: American Journal of Human Genetics, Vol. 49, No. 3, 01.09.1991, p. 682-686.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cleft lip and palate
T2 - No evidence of linkage to transforming growth factor alpha
AU - Hecht, Jacqueline T.
AU - Wang, Taping
AU - Blanton, Susan H
AU - Michels, Virginia V.
AU - Daiger, Stephen P.
PY - 1991/9/1
Y1 - 1991/9/1
N2 - Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.
AB - Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clef ting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at θ = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026092169&partnerID=8YFLogxK
M3 - Article
C2 - 1679292
AN - SCOPUS:0026092169
VL - 49
SP - 682
EP - 686
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 3
ER -