Clearance of ethylene glycol by kidneys and hemcdialysis

J. T. Cheng, T. D. Beysolow, B. Kaul, Richard S Weisman, D. A. Feinfeld

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A patient with acute ethylene glycol poisoning was treated with ethanol administration and hemodialysis, and his renal function remained consistently normal. Serial measurements of serum and urine levels of urea, creatinine, ethylene glycol, and ethanol were performed to compare the relative contributions of the hemodialyzer and the patient's kidneys in clearing ethylene glycol from the blood. Simultaneous measurements of the serum osmolal gap (corrected for ethanol) and anion gap were correlated with these data. Mean renal clearance of ethylene glycol was 27.5 ± 4.1 ml/min, with a fractional ethylene glycol excretion of 19.8 ± 1.5% This was lower than the mean urea clearance of 89.4 ± 11.0 ml/min and fractional urea excretion of 66.0 ± 7.8% Hemodialyzer clearance of ethylene glycol was 156 ml/min. There was a nearly exact correlation between the serum ethylene glycol level and the corrected osmolal gap (r = 0.998, p < 0.01). The calculated renal elimination half-life of ethylene glycol was 18 hr. We conclude that with a moderate diuresis, the normal human kidney contributes significantly to the removal of ethylene glycol from the blood. Corrected serum osmolal gap provides a nearly exact approximation of the serum ethylene glycol level and is a useful therapeutic guide.

Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalClinical Toxicology
Volume25
Issue number1-2
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Ethylene Glycol
Kidney
Hemodialyzers
Artificial Kidneys
Urea
Serum
Ethanol
Blood
Acid-Base Equilibrium
Diuresis
Poisoning
Half-Life
Renal Dialysis
Creatinine
Urine

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Cheng, J. T., Beysolow, T. D., Kaul, B., Weisman, R. S., & Feinfeld, D. A. (1987). Clearance of ethylene glycol by kidneys and hemcdialysis. Clinical Toxicology, 25(1-2), 95-108. https://doi.org/10.3109/15563658708992616

Clearance of ethylene glycol by kidneys and hemcdialysis. / Cheng, J. T.; Beysolow, T. D.; Kaul, B.; Weisman, Richard S; Feinfeld, D. A.

In: Clinical Toxicology, Vol. 25, No. 1-2, 1987, p. 95-108.

Research output: Contribution to journalArticle

Cheng, JT, Beysolow, TD, Kaul, B, Weisman, RS & Feinfeld, DA 1987, 'Clearance of ethylene glycol by kidneys and hemcdialysis', Clinical Toxicology, vol. 25, no. 1-2, pp. 95-108. https://doi.org/10.3109/15563658708992616
Cheng, J. T. ; Beysolow, T. D. ; Kaul, B. ; Weisman, Richard S ; Feinfeld, D. A. / Clearance of ethylene glycol by kidneys and hemcdialysis. In: Clinical Toxicology. 1987 ; Vol. 25, No. 1-2. pp. 95-108.
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