Clear cell acanthoma on the areola

Luis J. Borda, Joshua S. Mervis, Paolo Romanelli, Hadar Lev-Tovv

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3 Scopus citations


Clear cell acanthoma (CCA) is a rare, benign cutaneous condition most often seen on the lower extremities. Lesions are of variable morphology and have been described as polypoid, pigmented, giant, and cystic lesions. Although no racial or gender predilection has been reported, CCA on the breast is a very rare finding that has been observed mainly in young Korean women. Herein, we describe a case of CCA of the areola in an elderly woman with metastatic renal cell carcinoma. Physical exam revealed a pink plaque with central erosions on the left areola. Given the concern for cutaneous metastasis, excisional biopsy was performed, which showed pale glycogenated epithelium consistent with CCA. No evidence of recurrence or new lesions was observed after 6 months of follow-up. Our case exemplifies that clinicians should consider CCA in the differential diagnosis for a new eczematous lesion involving the breast, even in the setting of malignancy.

Original languageEnglish (US)
Article number17
JournalDermatology online journal
Issue number7
StatePublished - Jul 2018


  • Areola
  • Breast
  • Clear cell acanthoma
  • Metastasis
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Dermatology


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