Class i MHC molecules and doxorubicin resistant p388 murine leukemic cells

Linda M. Dicicco, Herbert Lazarus, Awtar Krishan

Research output: Contribution to journalArticle

Abstract

The major histocompatibility complex (MHC) encodes cell surface and secreted products involved in immune regulation and function. We have measured Class I MHC expression on doxorubicin (DOX) sensitive (P388/S) and resistant (P388/R84 and R84A) murine tumor cells using a monoclonal antibody to H-2d molecules. The present report shows a correlation between increased Class I MHC (H-2d) expression and drug resistance in P388 cells. Exposure of P388 cells to H-2d antibody diminished H-2d expression, whereas, treatment with murine recombinant γinterferon increased H-2d expression. Neither treatment significantly altered cellular DOX resistance or chemosensitivity. Thus, H-2d molecules can be used to identify DOX resistant P388 tumor cells but are probably not involved functionally in drug resistance.

Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Volume11
Issue number4
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Major Histocompatibility Complex
Doxorubicin
Molecules
Tumors
Cells
Drug Resistance
Pharmaceutical Preparations
Interferons
Monoclonal Antibodies
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Class i MHC molecules and doxorubicin resistant p388 murine leukemic cells. / Dicicco, Linda M.; Lazarus, Herbert; Krishan, Awtar.

In: Immunopharmacology and Immunotoxicology, Vol. 11, No. 4, 01.01.1989, p. 583-591.

Research output: Contribution to journalArticle

Dicicco, Linda M. ; Lazarus, Herbert ; Krishan, Awtar. / Class i MHC molecules and doxorubicin resistant p388 murine leukemic cells. In: Immunopharmacology and Immunotoxicology. 1989 ; Vol. 11, No. 4. pp. 583-591.
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