Class i MHC molecules and doxorubicin resistant p388 murine leukemic cells

Linda M. Dicicco, Herbert Lazarus, Awtar Krishan

Research output: Contribution to journalArticlepeer-review


The major histocompatibility complex (MHC) encodes cell surface and secreted products involved in immune regulation and function. We have measured Class I MHC expression on doxorubicin (DOX) sensitive (P388/S) and resistant (P388/R84 and R84A) murine tumor cells using a monoclonal antibody to H-2d molecules. The present report shows a correlation between increased Class I MHC (H-2d) expression and drug resistance in P388 cells. Exposure of P388 cells to H-2d antibody diminished H-2d expression, whereas, treatment with murine recombinant γinterferon increased H-2d expression. Neither treatment significantly altered cellular DOX resistance or chemosensitivity. Thus, H-2d molecules can be used to identify DOX resistant P388 tumor cells but are probably not involved functionally in drug resistance.

Original languageEnglish (US)
Pages (from-to)583-591
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology


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