Citrulline Evaluation in Bowel Transplantation

Phillip Ruiz, P. Tryphonopoulos, E. Island, Gennaro Selvaggi, Seigo Nishida, J. Moon, A. Berlanga, T. Defranc, D. Levi, Akin Tekin, A. G. Tzakis

Research output: Contribution to journalArticle

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Abstract

Introduction: The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation. Methods: From January 2007 until present, we performed citrulline assays on our small bowel patients. We investigated the correlation of these assays with the rejection status of the patients. The rejection status of the graft was defined based on graft biopsies. Results: Of 5195 citrulline samples, average serum citrulline levels decreased significantly when the patients presented a rejection episode. We found the following: no rejection, 17.38 μm/L; mild rejection, 13.05 μm/L; moderate rejection, 7.98 μm/L; and severe rejection, 6.05 μm/L. Our current emphasis is to determine the predictive power of citrulline with other biomarkers versus as a separate and isolated measurement. Conclusions: In our study, citrulline levels correlated significantly with the rejection status of the graft. Serial follow-up of the patients using this assay may alert us to the possibility of increased alloreactivity and rejection episodes.

Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalTransplantation Proceedings
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2010

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Citrulline
Transplantation
Graft Rejection
Biomarkers
Transplants
Biopsy
Serum

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Ruiz, P., Tryphonopoulos, P., Island, E., Selvaggi, G., Nishida, S., Moon, J., ... Tzakis, A. G. (2010). Citrulline Evaluation in Bowel Transplantation. Transplantation Proceedings, 42(1), 54-56. https://doi.org/10.1016/j.transproceed.2009.12.029

Citrulline Evaluation in Bowel Transplantation. / Ruiz, Phillip; Tryphonopoulos, P.; Island, E.; Selvaggi, Gennaro; Nishida, Seigo; Moon, J.; Berlanga, A.; Defranc, T.; Levi, D.; Tekin, Akin; Tzakis, A. G.

In: Transplantation Proceedings, Vol. 42, No. 1, 01.01.2010, p. 54-56.

Research output: Contribution to journalArticle

Ruiz, P, Tryphonopoulos, P, Island, E, Selvaggi, G, Nishida, S, Moon, J, Berlanga, A, Defranc, T, Levi, D, Tekin, A & Tzakis, AG 2010, 'Citrulline Evaluation in Bowel Transplantation', Transplantation Proceedings, vol. 42, no. 1, pp. 54-56. https://doi.org/10.1016/j.transproceed.2009.12.029
Ruiz, Phillip ; Tryphonopoulos, P. ; Island, E. ; Selvaggi, Gennaro ; Nishida, Seigo ; Moon, J. ; Berlanga, A. ; Defranc, T. ; Levi, D. ; Tekin, Akin ; Tzakis, A. G. / Citrulline Evaluation in Bowel Transplantation. In: Transplantation Proceedings. 2010 ; Vol. 42, No. 1. pp. 54-56.
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