Abstract
Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.
Original language | English (US) |
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Pages (from-to) | 423-431 |
Number of pages | 9 |
Journal | Lasers in Surgery and Medicine |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - Nov 20 1997 |
Externally published | Yes |
Keywords
- Cisplatinum
- Interstitial laser therapy
- Squamous cell carcinoma
ASJC Scopus subject areas
- Surgery