Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

M. B. Paiva; R. E. Saxton; Q. M. VanderWerf; T. Bell; A. A. Eshraghi; I. P. Graeber; J. Feyh; D. J. Castro

doi:10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S

Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

M. B. Paiva, R. E. Saxton, Q. M. VanderWerf, T. Bell, A. A. Eshraghi, I. P. Graeber, J. Feyh, D. J. Castro

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

Original language	English (US)
Pages (from-to)	423-431
Number of pages	9
Journal	Lasers in Surgery and Medicine
Volume	21
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S
State	Published - Nov 20 1997
Externally published	Yes

Keywords

Cisplatinum
Interstitial laser therapy
Squamous cell carcinoma

ASJC Scopus subject areas

Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S

Cite this

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title = "Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study",

abstract = "Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.",

keywords = "Cisplatinum, Interstitial laser therapy, Squamous cell carcinoma",

author = "Paiva, {M. B.} and Saxton, {R. E.} and VanderWerf, {Q. M.} and T. Bell and Eshraghi, {A. A.} and Graeber, {I. P.} and J. Feyh and Castro, {D. J.}",

year = "1997",

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doi = "10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S",

language = "English (US)",

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TY - JOUR

T1 - Cisplatinum and interstitial laser therapy for advanced head and neck cancer

T2 - A preclinical study

AU - Paiva, M. B.

AU - Saxton, R. E.

AU - VanderWerf, Q. M.

AU - Bell, T.

AU - Eshraghi, A. A.

AU - Graeber, I. P.

AU - Feyh, J.

AU - Castro, D. J.

PY - 1997/11/20

Y1 - 1997/11/20

N2 - Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

AB - Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

KW - Cisplatinum

KW - Interstitial laser therapy

KW - Squamous cell carcinoma

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Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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