Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

M. B. Paiva; R. E. Saxton; Q. M. VanderWerf; T. Bell; A. A. Eshraghi; I. P. Graeber; J. Feyh; D. J. Castro

doi:10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S

Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

M. B. Paiva, R. E. Saxton, Q. M. VanderWerf, T. Bell, A. A. Eshraghi, I. P. Graeber, J. Feyh, D. J. Castro

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

Original language	English (US)
Pages (from-to)	423-431
Number of pages	9
Journal	Lasers in Surgery and Medicine
Volume	21
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S
State	Published - Nov 20 1997
Externally published	Yes

Keywords

Cisplatinum
Interstitial laser therapy
Squamous cell carcinoma

ASJC Scopus subject areas

Surgery

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10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S

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Cite this

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title = "Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study",

abstract = "Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.",

keywords = "Cisplatinum, Interstitial laser therapy, Squamous cell carcinoma",

author = "Paiva, {M. B.} and Saxton, {R. E.} and VanderWerf, {Q. M.} and T. Bell and Eshraghi, {A. A.} and Graeber, {I. P.} and J. Feyh and Castro, {D. J.}",

year = "1997",

month = nov,

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doi = "10.1002/(SICI)1096-9101(1997)21:5<423::AID-LSM3>3.0.CO;2-S",

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T1 - Cisplatinum and interstitial laser therapy for advanced head and neck cancer

T2 - A preclinical study

AU - Paiva, M. B.

AU - Saxton, R. E.

AU - VanderWerf, Q. M.

AU - Bell, T.

AU - Eshraghi, A. A.

AU - Graeber, I. P.

AU - Feyh, J.

AU - Castro, D. J.

PY - 1997/11/20

Y1 - 1997/11/20

N2 - Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

AB - Background and Objective: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as se transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

KW - Cisplatinum

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KW - Squamous cell carcinoma

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