Cis interactions make immune checkpoint blockade more trans-parent

Natasha Khatwani, Asha B. Pillai

Research output: Contribution to journalArticle

Abstract

PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

Original languageEnglish (US)
JournalScience immunology
Volume5
Issue number43
DOIs
StatePublished - Jan 2 2020
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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