Cis interactions make immune checkpoint blockade more trans-parent

Natasha Khatwani, Asha B. Pillai

Research output: Contribution to journalArticle

Abstract

PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

Original languageEnglish (US)
JournalScience immunology
Volume5
Issue number43
DOIs
StatePublished - Jan 2 2020

Fingerprint

T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cis interactions make immune checkpoint blockade more trans-parent. / Khatwani, Natasha; Pillai, Asha B.

In: Science immunology, Vol. 5, No. 43, 02.01.2020.

Research output: Contribution to journalArticle

@article{fd660c0202ec4335b48c1b347fc9cf41,
title = "Cis interactions make immune checkpoint blockade more trans-parent",
abstract = "PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.",
author = "Natasha Khatwani and Pillai, {Asha B.}",
year = "2020",
month = "1",
day = "2",
doi = "10.1126/sciimmunol.aba7107",
language = "English (US)",
volume = "5",
journal = "Science immunology",
issn = "2470-9468",
publisher = "American Association for the Advancement of Science",
number = "43",

}

TY - JOUR

T1 - Cis interactions make immune checkpoint blockade more trans-parent

AU - Khatwani, Natasha

AU - Pillai, Asha B.

PY - 2020/1/2

Y1 - 2020/1/2

N2 - PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

AB - PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

UR - http://www.scopus.com/inward/record.url?scp=85077480369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077480369&partnerID=8YFLogxK

U2 - 10.1126/sciimmunol.aba7107

DO - 10.1126/sciimmunol.aba7107

M3 - Article

C2 - 31901070

AN - SCOPUS:85077480369

VL - 5

JO - Science immunology

JF - Science immunology

SN - 2470-9468

IS - 43

ER -