cis and trans regulation of tissue-specific transcription

J. D. Engel, H. Beug, J. H. LaVail, M. W. Zenke, K. Mayo, M. W. Leonard, K. P. Foley, Z. Yang, J. M. Kornhauser, L. J. Ko, K. C. Lim, K. M. George, K. Breigel

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Analysis of both the cis-regulatory sequences which control globin gene switching as well as the trans-acting factors which bind to these sequences to elicit a differential, developmentally regulated response has lent insight into the general mechanisms responsible for tissue-specific gene regulation. We show here that the chicken adult β-globin gene promoter sequences are intimately involved in competitive interaction with the β/ε-globin enhancer to regulate differentially ε- versus β-globin gene transcription. Secondly, we show that the family of GATA transcription factors directs gene regulation in variety of discrete cell types, and describe potential cellular target genes for each member of the GATA factor family, as well as potential mechanisms whereby multiple GATA factors expressed in a single cell might be used to elicit differential transcriptional activities.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalJournal of Cell Science
Issue numberSUPPL. 16
StatePublished - 1992
Externally publishedYes


  • GATA
  • Globin gene switching
  • HIV
  • T lymphocytes
  • Transcription factor

ASJC Scopus subject areas

  • Cell Biology


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