Circumferential Resection of the Inferior Vena Cava for Primary and Recurrent Malignant Tumors

Jorge Caso, John Seigne, Martin Back, Phillipe E. Spiess, Julio Pow-Sang, Wade J. Sexton

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: Circumferential vena caval resection is occasionally performed in patients with advanced malignancy. We explored the oncological effectiveness of inferior vena caval resection, as determined by margin status, cancer recurrence and survival. Also, we addressed the morbidity associated with inferior vena caval obstruction and resection, and determined indications for inferior vena caval reconstruction. Materials and Methods: A total of 18 patients underwent attempted inferior vena caval resection from 1999 to 2008. Primary tumor type was renal cell carcinoma in 7 patients, metastatic testicular cancer in 5, leiomyosarcoma in 3, and adrenal cortical carcinoma, primary retroperitoneal germ cell tumor and upper tract transitional cell carcinoma in 1 each. Data reviewed included preoperative and postoperative sequelae of inferior vena caval obstruction, postoperative complications, pathological results, cancer recurrence, graft requirements and functional outcomes. Results: Mean followup in the entire patient cohort was 24 months. Inferior vena caval resection was completed in 15 of 18 patients, of whom 12 (80%) had negative surgical margins. Of the patients 50% presented with symptoms of venous hypertension, including lower extremity edema with or without venous thrombosis, or abdominal wall varicosity. After inferior vena caval resection symptoms resolved in half of them, likely due to the ongoing formation of collateral vessels. Five asymptomatic patients with incomplete inferior vena caval occlusion underwent reconstruction with inferior vena caval vascular grafts of polytetrafluoroethylene (4) or Dacron® (1). The polytetrafluoroethylene grafts remained patent. A total of 12 patients underwent simultaneous nephrectomy and/or left renal vein ligation in the same setting with acceptable alterations in postoperative renal function and no need for permanent dialysis. Cancer recurred locally in 4 of 15 patients who underwent resection. Five of 15 patients in the resection group died of disease or were lost to followup compared to all 3 in whom resection was aborted or macroscopically incomplete (mean followup 19.2 vs 4.3 months). Conclusions: Local cancer control and potentially increased cancer specific survival can be achieved with successful complete circumferential resection of the inferior vena cava as a component of multimodality care in select patients with locally advanced malignancy. Polytetrafluoroethylene is the preferred prosthetic material when inferior vena caval replacement is indicated. The most common postoperative complications are renal insufficiency and lower extremity edema, which are generally transient.

Original languageEnglish
Pages (from-to)887-893
Number of pages7
JournalJournal of Urology
Volume182
Issue number3
DOIs
StatePublished - Sep 1 2009

Fingerprint

Venae Cavae
Inferior Vena Cava
Neoplasms
Polytetrafluoroethylene
Transplants
Lower Extremity
Edema
Adrenocortical Carcinoma
Recurrence
Polyethylene Terephthalates
Renal Veins
Survival
Leiomyosarcoma
Transitional Cell Carcinoma
Germ Cell and Embryonal Neoplasms
Testicular Neoplasms
Abdominal Wall
Nephrectomy
Renal Cell Carcinoma
Venous Thrombosis

Keywords

  • inferior
  • kidney
  • neoplasms
  • prostheses and implants
  • testis
  • vena cava

ASJC Scopus subject areas

  • Urology

Cite this

Caso, J., Seigne, J., Back, M., Spiess, P. E., Pow-Sang, J., & Sexton, W. J. (2009). Circumferential Resection of the Inferior Vena Cava for Primary and Recurrent Malignant Tumors. Journal of Urology, 182(3), 887-893. https://doi.org/10.1016/j.juro.2009.05.015

Circumferential Resection of the Inferior Vena Cava for Primary and Recurrent Malignant Tumors. / Caso, Jorge; Seigne, John; Back, Martin; Spiess, Phillipe E.; Pow-Sang, Julio; Sexton, Wade J.

In: Journal of Urology, Vol. 182, No. 3, 01.09.2009, p. 887-893.

Research output: Contribution to journalArticle

Caso, J, Seigne, J, Back, M, Spiess, PE, Pow-Sang, J & Sexton, WJ 2009, 'Circumferential Resection of the Inferior Vena Cava for Primary and Recurrent Malignant Tumors', Journal of Urology, vol. 182, no. 3, pp. 887-893. https://doi.org/10.1016/j.juro.2009.05.015
Caso, Jorge ; Seigne, John ; Back, Martin ; Spiess, Phillipe E. ; Pow-Sang, Julio ; Sexton, Wade J. / Circumferential Resection of the Inferior Vena Cava for Primary and Recurrent Malignant Tumors. In: Journal of Urology. 2009 ; Vol. 182, No. 3. pp. 887-893.
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abstract = "Purpose: Circumferential vena caval resection is occasionally performed in patients with advanced malignancy. We explored the oncological effectiveness of inferior vena caval resection, as determined by margin status, cancer recurrence and survival. Also, we addressed the morbidity associated with inferior vena caval obstruction and resection, and determined indications for inferior vena caval reconstruction. Materials and Methods: A total of 18 patients underwent attempted inferior vena caval resection from 1999 to 2008. Primary tumor type was renal cell carcinoma in 7 patients, metastatic testicular cancer in 5, leiomyosarcoma in 3, and adrenal cortical carcinoma, primary retroperitoneal germ cell tumor and upper tract transitional cell carcinoma in 1 each. Data reviewed included preoperative and postoperative sequelae of inferior vena caval obstruction, postoperative complications, pathological results, cancer recurrence, graft requirements and functional outcomes. Results: Mean followup in the entire patient cohort was 24 months. Inferior vena caval resection was completed in 15 of 18 patients, of whom 12 (80{\%}) had negative surgical margins. Of the patients 50{\%} presented with symptoms of venous hypertension, including lower extremity edema with or without venous thrombosis, or abdominal wall varicosity. After inferior vena caval resection symptoms resolved in half of them, likely due to the ongoing formation of collateral vessels. Five asymptomatic patients with incomplete inferior vena caval occlusion underwent reconstruction with inferior vena caval vascular grafts of polytetrafluoroethylene (4) or Dacron{\circledR} (1). The polytetrafluoroethylene grafts remained patent. A total of 12 patients underwent simultaneous nephrectomy and/or left renal vein ligation in the same setting with acceptable alterations in postoperative renal function and no need for permanent dialysis. Cancer recurred locally in 4 of 15 patients who underwent resection. Five of 15 patients in the resection group died of disease or were lost to followup compared to all 3 in whom resection was aborted or macroscopically incomplete (mean followup 19.2 vs 4.3 months). Conclusions: Local cancer control and potentially increased cancer specific survival can be achieved with successful complete circumferential resection of the inferior vena cava as a component of multimodality care in select patients with locally advanced malignancy. Polytetrafluoroethylene is the preferred prosthetic material when inferior vena caval replacement is indicated. The most common postoperative complications are renal insufficiency and lower extremity edema, which are generally transient.",
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N2 - Purpose: Circumferential vena caval resection is occasionally performed in patients with advanced malignancy. We explored the oncological effectiveness of inferior vena caval resection, as determined by margin status, cancer recurrence and survival. Also, we addressed the morbidity associated with inferior vena caval obstruction and resection, and determined indications for inferior vena caval reconstruction. Materials and Methods: A total of 18 patients underwent attempted inferior vena caval resection from 1999 to 2008. Primary tumor type was renal cell carcinoma in 7 patients, metastatic testicular cancer in 5, leiomyosarcoma in 3, and adrenal cortical carcinoma, primary retroperitoneal germ cell tumor and upper tract transitional cell carcinoma in 1 each. Data reviewed included preoperative and postoperative sequelae of inferior vena caval obstruction, postoperative complications, pathological results, cancer recurrence, graft requirements and functional outcomes. Results: Mean followup in the entire patient cohort was 24 months. Inferior vena caval resection was completed in 15 of 18 patients, of whom 12 (80%) had negative surgical margins. Of the patients 50% presented with symptoms of venous hypertension, including lower extremity edema with or without venous thrombosis, or abdominal wall varicosity. After inferior vena caval resection symptoms resolved in half of them, likely due to the ongoing formation of collateral vessels. Five asymptomatic patients with incomplete inferior vena caval occlusion underwent reconstruction with inferior vena caval vascular grafts of polytetrafluoroethylene (4) or Dacron® (1). The polytetrafluoroethylene grafts remained patent. A total of 12 patients underwent simultaneous nephrectomy and/or left renal vein ligation in the same setting with acceptable alterations in postoperative renal function and no need for permanent dialysis. Cancer recurred locally in 4 of 15 patients who underwent resection. Five of 15 patients in the resection group died of disease or were lost to followup compared to all 3 in whom resection was aborted or macroscopically incomplete (mean followup 19.2 vs 4.3 months). Conclusions: Local cancer control and potentially increased cancer specific survival can be achieved with successful complete circumferential resection of the inferior vena cava as a component of multimodality care in select patients with locally advanced malignancy. Polytetrafluoroethylene is the preferred prosthetic material when inferior vena caval replacement is indicated. The most common postoperative complications are renal insufficiency and lower extremity edema, which are generally transient.

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