Circulatory TGF-β1 is signifcantly higher in early stage of pulmonary sarcoidosis

Mehdi Mirsaeidi, Hesham R. Omar, Andrew Calzadilla, Ahmad El Khatib, Philip Whitney, Nadera Sweiss, Daniel Culver, Michael A Campos, Robert Baughman, Roberto MacHado

Research output: Contribution to journalArticle

Abstract

Introduction: Te pathogenesis of pulmonary fbrosis in sarcoidosis is not known. We hypothesized that higher levels of circulatory growth factors are present in early stages of pulmonary sarcoidosis and may be associated with pulmonary fbrosis. Methods: Age and sex-matched subjects with sarcoidosis stage 0-1 (n=18), stage 4-5 (n=13) and healthy controls (n=5) had their serum TGF-ß1, FGF, and VEGF levels measured as well as their gene expressions determined in peripheral blood mononuclear cells. Results: TGF-ß1 levels were signifcantly higher in patients with stage 0-1 sarcoidosis compared with normal healthy control patients (25,488 vs. 13800 pg/ml, P=0.05). Patients with sarcoidosis stage 4 had a 1.3-fold higher peripheral blood mononuclear cells (PBMC) gene expression of TGF-ß1 compared with subjects at stage 0-1 (P= 0.041). Te serum levels of FGF, and VEGF had a trend towards higher levels in sarcoidosis subjects compared to normal controls. Conclusion: Tese results suggest that cell growth factors levels are high in early stages of sarcoidosis. Tese fndings should be validated in larger studies.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume35
Issue number3
StatePublished - Oct 18 2018

Keywords

  • And VEGF
  • FGF
  • Growth factor
  • Sarcoidosis
  • TGF-β1

ASJC Scopus subject areas

  • Internal Medicine
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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