Circulating tumor cell capture from whole blood by parylene filter devices

Siyang Zheng, Yu Chong Tai, Henry Lin, Marija Balic, Ram Datar, Richard J Cote

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We report here design, fabrication and testing of parylene membrane filter device for capturing circulating tumor cell (CTC) from undiluted human peripheral blood. To our knowledge, this is the first micromachined membrane filter used for rare CTC detection. Even without much optimization, the device already demonstrates 89% recovery and 9 log10 enrichment and out-performs most current methods used in the field [1]. Moreover, less than 10 minutes are required for each sample separation, compared to current multistep processing needing > 1 hour.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages874-876
Number of pages3
Volume1
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Externally publishedYes
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Fingerprint

Tumors
Blood
Cells
Membranes
Fabrication
Recovery
Testing
Processing
parylene

Keywords

  • Blood
  • Filter
  • Tumor cell

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Zheng, S., Tai, Y. C., Lin, H., Balic, M., Datar, R., & Cote, R. J. (2005). Circulating tumor cell capture from whole blood by parylene filter devices. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Vol. 1, pp. 874-876). Transducer Research Foundation.

Circulating tumor cell capture from whole blood by parylene filter devices. / Zheng, Siyang; Tai, Yu Chong; Lin, Henry; Balic, Marija; Datar, Ram; Cote, Richard J.

Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Vol. 1 Transducer Research Foundation, 2005. p. 874-876.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zheng, S, Tai, YC, Lin, H, Balic, M, Datar, R & Cote, RJ 2005, Circulating tumor cell capture from whole blood by parylene filter devices. in Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. vol. 1, Transducer Research Foundation, pp. 874-876, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005, Boston, MA, United States, 10/9/05.
Zheng S, Tai YC, Lin H, Balic M, Datar R, Cote RJ. Circulating tumor cell capture from whole blood by parylene filter devices. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Vol. 1. Transducer Research Foundation. 2005. p. 874-876
Zheng, Siyang ; Tai, Yu Chong ; Lin, Henry ; Balic, Marija ; Datar, Ram ; Cote, Richard J. / Circulating tumor cell capture from whole blood by parylene filter devices. Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Vol. 1 Transducer Research Foundation, 2005. pp. 874-876
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