CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY

V. Lewis, J. J. Twomey, G. Goldstein, E. Smithwick, Savita G Pahwa, R. O'Reilly, Rajendra Pahwa, R. A. Good, H. Schulte-Wisserman, S. Horowitz, R. Hong, J. Jones, O. Sieber, C. Kirkpatrick, S. Polmar, P. Bealmear

Research output: Contribution to journalArticle

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Abstract

Circulating thymic-hormone activity was assayed by measuring Thy 1·2 antigen induction on null lymphocytes from athymic mice incubated with human plasma or serum. Plasma from 19 normal children aged under 10 had inductive activity equivalent to 10·6-16·2 ng thymopoietin/ml. Plasma from 15 infants with severe combined immunodeficiency, 2 of whom had appreciable immunoglobulin synthesis, and from 2 infants with DiGeorge syndrome had little or no inductive activity. Successful reconstitution with thymus or bone-marrow grafts and with redcell infusions (if adenosine-deaminase deficiency is present) was followed by a rise in circulating thymic-hormone activity.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalThe Lancet
Volume310
Issue number8036
DOIs
StatePublished - Sep 3 1977
Externally publishedYes

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Thymus Hormones
Thymopoietins
Wiskott-Aldrich Syndrome
DiGeorge Syndrome
Severe Combined Immunodeficiency
Null Lymphocytes
Nude Mice
Thymus Gland
Immunoglobulins
Bone Marrow
Transplants
Antigens
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lewis, V., Twomey, J. J., Goldstein, G., Smithwick, E., Pahwa, S. G., O'Reilly, R., ... Bealmear, P. (1977). CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY. The Lancet, 310(8036), 471-475. https://doi.org/10.1016/S0140-6736(77)91601-4

CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY. / Lewis, V.; Twomey, J. J.; Goldstein, G.; Smithwick, E.; Pahwa, Savita G; O'Reilly, R.; Pahwa, Rajendra; Good, R. A.; Schulte-Wisserman, H.; Horowitz, S.; Hong, R.; Jones, J.; Sieber, O.; Kirkpatrick, C.; Polmar, S.; Bealmear, P.

In: The Lancet, Vol. 310, No. 8036, 03.09.1977, p. 471-475.

Research output: Contribution to journalArticle

Lewis, V, Twomey, JJ, Goldstein, G, Smithwick, E, Pahwa, SG, O'Reilly, R, Pahwa, R, Good, RA, Schulte-Wisserman, H, Horowitz, S, Hong, R, Jones, J, Sieber, O, Kirkpatrick, C, Polmar, S & Bealmear, P 1977, 'CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY', The Lancet, vol. 310, no. 8036, pp. 471-475. https://doi.org/10.1016/S0140-6736(77)91601-4
Lewis V, Twomey JJ, Goldstein G, Smithwick E, Pahwa SG, O'Reilly R et al. CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY. The Lancet. 1977 Sep 3;310(8036):471-475. https://doi.org/10.1016/S0140-6736(77)91601-4
Lewis, V. ; Twomey, J. J. ; Goldstein, G. ; Smithwick, E. ; Pahwa, Savita G ; O'Reilly, R. ; Pahwa, Rajendra ; Good, R. A. ; Schulte-Wisserman, H. ; Horowitz, S. ; Hong, R. ; Jones, J. ; Sieber, O. ; Kirkpatrick, C. ; Polmar, S. ; Bealmear, P. / CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY. In: The Lancet. 1977 ; Vol. 310, No. 8036. pp. 471-475.
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AU - Pahwa, Savita G

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