CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY

V. Lewis, J. J. Twomey, G. Goldstein, E. Smithwick, S. Pahwa, R. O'Reilly, Rajendra Pahwa, R. A. Good, H. Schulte-Wisserman, S. Horowitz, R. Hong, J. Jones, O. Sieber, C. Kirkpatrick, S. Polmar, P. Bealmear

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Circulating thymic-hormone activity was assayed by measuring Thy 1·2 antigen induction on null lymphocytes from athymic mice incubated with human plasma or serum. Plasma from 19 normal children aged under 10 had inductive activity equivalent to 10·6-16·2 ng thymopoietin/ml. Plasma from 15 infants with severe combined immunodeficiency, 2 of whom had appreciable immunoglobulin synthesis, and from 2 infants with DiGeorge syndrome had little or no inductive activity. Successful reconstitution with thymus or bone-marrow grafts and with redcell infusions (if adenosine-deaminase deficiency is present) was followed by a rise in circulating thymic-hormone activity.

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalThe Lancet
Volume310
Issue number8036
DOIs
StatePublished - Sep 3 1977
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Lewis, V., Twomey, J. J., Goldstein, G., Smithwick, E., Pahwa, S., O'Reilly, R., Pahwa, R., Good, R. A., Schulte-Wisserman, H., Horowitz, S., Hong, R., Jones, J., Sieber, O., Kirkpatrick, C., Polmar, S., & Bealmear, P. (1977). CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY. The Lancet, 310(8036), 471-475. https://doi.org/10.1016/S0140-6736(77)91601-4