Circulating levels of glucocorticoid hormones in WHHL and NZW rabbits: Circadian cycle and response to repeated social encounter

Angela Szeto, J. A. Gonzales, S. B. Spitzer, J. E. Levine, Julia Zaias, Patrice Saab, Neil Schneiderman, Philip McCabe

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Social environment influences the progression of atherosclerosis in an important experimental model of disease, the Watanabe Heritable Hyperlipidemic rabbit (WHHL). Although the hypothalamic-pituitary-adrenocortical (HPA) system is likely to play an important role in the behavioral modulation of disease, relatively little is known about the glucocorticoid responses in these animals, or in other strains of rabbits. The purpose of the present study was to: (1) evaluate the rabbit glucocorticoid circadian rhythm, (2) compare plasma cortisol and corticosterone responses to social stress, and (3) examine strain differences (i.e., WHHL vs. New Zealand White (NZW)) in rabbit glucocorticoid responses to assess whether WHHLs have an aberrant HPA system. It was found that male rabbits secrete both corticosterone and cortisol in a circadian rhythm that peaks in the afternoon and reaches a nadir at 0600 h, i.e., approximately 12 h out-of-phase with the human glucocorticoid rhythm. Both glucocorticoids responded similarly to social stress induced by repeated daily 4 h pairings with another male rabbit; after 10 days of pairings, glucorticoid values were significantly correlated with the amount of defensive agonistic behavior exhibited. Finally, there were no significant strain differences in glucocorticoid circadian rhythms, baselines, or responses to social stress. These data suggest that glucocorticoid responses (i.e., circadian rhythms, responses to social stress) in the WHHL are similar to glucocorticoid responses in standard laboratory white rabbits.

Original languageEnglish
Pages (from-to)861-866
Number of pages6
JournalPsychoneuroendocrinology
Volume29
Issue number7
DOIs
StatePublished - Aug 1 2004

Fingerprint

Glucocorticoids
Hormones
Rabbits
Circadian Rhythm
Corticosterone
Hydrocortisone
Agonistic Behavior
Social Environment
Cerebral Palsy
Atherosclerosis
Theoretical Models

Keywords

  • Circadian rhythm
  • Corticosterone
  • Cortisol
  • Rabbit
  • Social stress
  • WHHL

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

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title = "Circulating levels of glucocorticoid hormones in WHHL and NZW rabbits: Circadian cycle and response to repeated social encounter",
abstract = "Social environment influences the progression of atherosclerosis in an important experimental model of disease, the Watanabe Heritable Hyperlipidemic rabbit (WHHL). Although the hypothalamic-pituitary-adrenocortical (HPA) system is likely to play an important role in the behavioral modulation of disease, relatively little is known about the glucocorticoid responses in these animals, or in other strains of rabbits. The purpose of the present study was to: (1) evaluate the rabbit glucocorticoid circadian rhythm, (2) compare plasma cortisol and corticosterone responses to social stress, and (3) examine strain differences (i.e., WHHL vs. New Zealand White (NZW)) in rabbit glucocorticoid responses to assess whether WHHLs have an aberrant HPA system. It was found that male rabbits secrete both corticosterone and cortisol in a circadian rhythm that peaks in the afternoon and reaches a nadir at 0600 h, i.e., approximately 12 h out-of-phase with the human glucocorticoid rhythm. Both glucocorticoids responded similarly to social stress induced by repeated daily 4 h pairings with another male rabbit; after 10 days of pairings, glucorticoid values were significantly correlated with the amount of defensive agonistic behavior exhibited. Finally, there were no significant strain differences in glucocorticoid circadian rhythms, baselines, or responses to social stress. These data suggest that glucocorticoid responses (i.e., circadian rhythms, responses to social stress) in the WHHL are similar to glucocorticoid responses in standard laboratory white rabbits.",
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AU - Szeto, Angela

AU - Gonzales, J. A.

AU - Spitzer, S. B.

AU - Levine, J. E.

AU - Zaias, Julia

AU - Saab, Patrice

AU - Schneiderman, Neil

AU - McCabe, Philip

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