Circulating leptin and stress-induced cardiovascular activity in humans

Lena Brydon, Katie O'Donnell, Caroline E. Wright, Andrew Wawrzyniak, Jane Wardle, Andrew Steptoe

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Obesity is associated with an elevated risk of hypertension and cardiovascular disease. The adipocyte hormone leptin, which stimulates energy expenditure in animals by activating the sympathetic nervous system (SNS), is believed to play a role in this association. However, evidence in humans remains sparse. We investigated the relationship between circulating leptin and cardiovascular and inflammatory responses to acute psychological stress in humans. Participants were 32 men and 62 women aged 18-25 years. Cardiovascular activity was assessed using impedance cardiography at baseline, during acute laboratory stress, and during a 45-min recovery period. Plasma cytokines were measured in blood drawn at baseline and 45-min poststress. In women only, baseline plasma leptin was significantly associated with stress-induced changes in heart rate (Β = 0.53, P = 0.006), heart rate variability (HRV) (Β = -0.44, P = 0.015), and cardiac preejection period (PEP) (Β = -0.51, P = 0.004), independent of age, adiposity, and smoking. Women's plasma leptin levels also correlated with stress-induced elevations in the proinflammatory cytokine interleukin-6 (IL-6) (Β = 0.35, P = 0.042). Circulating leptin is an independent predictor of sympathetic cardiovascular activity, parasympathetic withdrawal, and inflammatory responses to stress in women. Because cardiovascular and inflammatory stress responses are predictive of future cardiovascular disease, leptin may be a mechanism mediating the adverse effects of stress and obesity on women's cardiovascular health.

Original languageEnglish
Pages (from-to)2642-2647
Number of pages6
JournalObesity
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Fingerprint

Leptin
Human Activities
Cardiovascular Diseases
Obesity
Heart Rate
Impedance Cardiography
Cytokines
Sympathetic Nervous System
Adiposity
Women's Health
Psychological Stress
Adipocytes
Energy Metabolism
Interleukin-6
Smoking
Hormones
Hypertension

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Brydon, L., O'Donnell, K., Wright, C. E., Wawrzyniak, A., Wardle, J., & Steptoe, A. (2008). Circulating leptin and stress-induced cardiovascular activity in humans. Obesity, 16(12), 2642-2647. https://doi.org/10.1038/oby.2008.415

Circulating leptin and stress-induced cardiovascular activity in humans. / Brydon, Lena; O'Donnell, Katie; Wright, Caroline E.; Wawrzyniak, Andrew; Wardle, Jane; Steptoe, Andrew.

In: Obesity, Vol. 16, No. 12, 01.12.2008, p. 2642-2647.

Research output: Contribution to journalArticle

Brydon, L, O'Donnell, K, Wright, CE, Wawrzyniak, A, Wardle, J & Steptoe, A 2008, 'Circulating leptin and stress-induced cardiovascular activity in humans', Obesity, vol. 16, no. 12, pp. 2642-2647. https://doi.org/10.1038/oby.2008.415
Brydon L, O'Donnell K, Wright CE, Wawrzyniak A, Wardle J, Steptoe A. Circulating leptin and stress-induced cardiovascular activity in humans. Obesity. 2008 Dec 1;16(12):2642-2647. https://doi.org/10.1038/oby.2008.415
Brydon, Lena ; O'Donnell, Katie ; Wright, Caroline E. ; Wawrzyniak, Andrew ; Wardle, Jane ; Steptoe, Andrew. / Circulating leptin and stress-induced cardiovascular activity in humans. In: Obesity. 2008 ; Vol. 16, No. 12. pp. 2642-2647.
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