Circulating endothelial progenitor cells predict coronary artery disease severity

Geoffrey A. Kunz, Ge Liang, Florim Cuculoski, David Gregg, Korkut C. Vata, Linda K. Shaw, Pascal Goldschmidt-Clermont, Chunming Dong, Doris A. Taylor, Eric D. Peterson

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Background: Circulating endothelial progenitor cells (EPCs) may play an important role in the body's defense against atherosclerosis. Previous studies have shown an association between EPC numbers and the presence of traditional coronary artery disease (CAD) risk factors. The relationship between EPC numbers and the severity of atherosclerosis is, however, not known. Methods: EPC counts were measured by quantitative cell culture in 122 patients undergoing diagnostic cardiac catheterization. The association between patients' EPC count and the presence of multivessel CAD and traditional cardiac risk factors was assessed using logistic regression analysis. Results: The median age of the study population was 58 years; 37% had multivessel CAD, 29% had diabetes, and 14% had myocardial infarction this admission. EPC counts did not vary significantly with most established cardiac risk factors but were lower in diabetics versus nondiabetics and trended toward lower numbers in older patients. EPC count was the second strongest predictor of multivessel CAD, after patient age. Patients with multivessel disease had significantly lower EPC counts than those without (median, 3 vs 13; P < .0088). For every 10 colony forming unit increase in EPCs, a patient's likelihood for multivessel CAD declined by 20% (P < .001). Conclusion: This study demonstrates an inverse relationship between circulating EPCs and CAD severity, independent of traditional risk factors. If confirmed in ongoing studies, this may represent an important new diagnostic and therapeutic target for coronary disease treatment.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalAmerican Heart Journal
Volume152
Issue number1
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

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Coronary Artery Disease
Cell Count
Atherosclerosis
Endothelial Progenitor Cells
Cardiac Catheterization
Coronary Disease
Stem Cells
Cell Culture Techniques
Logistic Models
Myocardial Infarction
Regression Analysis
Therapeutics
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kunz, G. A., Liang, G., Cuculoski, F., Gregg, D., Vata, K. C., Shaw, L. K., ... Peterson, E. D. (2006). Circulating endothelial progenitor cells predict coronary artery disease severity. American Heart Journal, 152(1), 190-195. https://doi.org/10.1016/j.ahj.2006.02.001

Circulating endothelial progenitor cells predict coronary artery disease severity. / Kunz, Geoffrey A.; Liang, Ge; Cuculoski, Florim; Gregg, David; Vata, Korkut C.; Shaw, Linda K.; Goldschmidt-Clermont, Pascal; Dong, Chunming; Taylor, Doris A.; Peterson, Eric D.

In: American Heart Journal, Vol. 152, No. 1, 01.07.2006, p. 190-195.

Research output: Contribution to journalArticle

Kunz, GA, Liang, G, Cuculoski, F, Gregg, D, Vata, KC, Shaw, LK, Goldschmidt-Clermont, P, Dong, C, Taylor, DA & Peterson, ED 2006, 'Circulating endothelial progenitor cells predict coronary artery disease severity', American Heart Journal, vol. 152, no. 1, pp. 190-195. https://doi.org/10.1016/j.ahj.2006.02.001
Kunz, Geoffrey A. ; Liang, Ge ; Cuculoski, Florim ; Gregg, David ; Vata, Korkut C. ; Shaw, Linda K. ; Goldschmidt-Clermont, Pascal ; Dong, Chunming ; Taylor, Doris A. ; Peterson, Eric D. / Circulating endothelial progenitor cells predict coronary artery disease severity. In: American Heart Journal. 2006 ; Vol. 152, No. 1. pp. 190-195.
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