Circadian variations in radioligand binding to muscarine receptors in rat brain dependent upon endogenous agonist occupation

Deborah C. Mash, Donna D. Flynn, Lynn Kalinoski, Lincoln T. Potter

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Although total levels of muscarine receptors in the rat forebrain and brainstem are constant at different times of day, there are large circadian changes in the numbers and carbachol-affinities of unoccupied receptors, which appear to reflect varying levels of endogenous acetylcholine-receptor complexes and the activity of cholinergic synapses.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalBrain Research
Volume331
Issue number1
DOIs
StatePublished - Apr 1 1985

Keywords

  • acetylcholine
  • circadian rhythm
  • muscarine receptors

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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