Circadian clock mutants of cyanobacteria

Takao Kondo, Nicholas F. Tsinoremas, Susan S. Golden, Carl Hirschie Johnson, Shinsuke Kutsuna, Masahiro Ishiura

Research output: Contribution to journalArticle

235 Scopus citations


A diverse set of circadian clock mutants was isolated in a cyanobacterial strain that carries a bacterial luciferase reporter gene attached to a clock-controlled promoter. Among 150,000 clones of chemically mutagenized bioluminescent cells, 12 mutants were isolated that exhibit a broad spectrum of periods (between 16 and 60 hours), and 5 mutants were found that show a variety of unusual patterns, including arrhythmia. These mutations appear to be clock-specific. Moreover, it was demonstrated that in this cyanobacterium it is possible to clone mutant genes by complementation, which provides a means to genetically dissect the circadian mechanism.

Original languageEnglish (US)
Pages (from-to)1233-1236
Number of pages4
Issue number5188
StatePublished - Jan 1 1994
Externally publishedYes

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    Kondo, T., Tsinoremas, N. F., Golden, S. S., Johnson, C. H., Kutsuna, S., & Ishiura, M. (1994). Circadian clock mutants of cyanobacteria. Science, 266(5188), 1233-1236.