Abstract
Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 × 10-11, corrected) and portions of posterior cingulate (p < .02, corrected). Conclusions: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 332-337 |
| Number of pages | 6 |
| Journal | Biological Psychiatry |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2008 |
| Externally published | Yes |
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Keywords
- ADHD
- anterior cingulate cortex
- default-mode network
- functional magnetic resonance imaging
- posterior cingulate cortex
- precuneus
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Cingulate-Precuneus Interactions : A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder. / Castellanos, F. Xavier; Margulies, Daniel S.; Kelly, Clare; Uddin, Lucina Q; Ghaffari, Manely; Kirsch, Andrew; Shaw, David; Shehzad, Zarrar; Di Martino, Adriana; Biswal, Bharat; Sonuga-Barke, Edmund J S; Rotrosen, John; Adler, Lenard A.; Milham, Michael P.
In: Biological Psychiatry, Vol. 63, No. 3, 01.02.2008, p. 332-337.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cingulate-Precuneus Interactions
T2 - A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder
AU - Castellanos, F. Xavier
AU - Margulies, Daniel S.
AU - Kelly, Clare
AU - Uddin, Lucina Q
AU - Ghaffari, Manely
AU - Kirsch, Andrew
AU - Shaw, David
AU - Shehzad, Zarrar
AU - Di Martino, Adriana
AU - Biswal, Bharat
AU - Sonuga-Barke, Edmund J S
AU - Rotrosen, John
AU - Adler, Lenard A.
AU - Milham, Michael P.
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 × 10-11, corrected) and portions of posterior cingulate (p < .02, corrected). Conclusions: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
AB - Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 × 10-11, corrected) and portions of posterior cingulate (p < .02, corrected). Conclusions: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
KW - ADHD
KW - anterior cingulate cortex
KW - default-mode network
KW - functional magnetic resonance imaging
KW - posterior cingulate cortex
KW - precuneus
UR - http://www.scopus.com/inward/record.url?scp=38049078773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38049078773&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2007.06.025
DO - 10.1016/j.biopsych.2007.06.025
M3 - Article
VL - 63
SP - 332
EP - 337
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 3
ER -