Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder

F. Xavier Castellanos, Daniel S. Margulies, Clare Kelly, Lucina Q Uddin, Manely Ghaffari, Andrew Kirsch, David Shaw, Zarrar Shehzad, Adriana Di Martino, Bharat Biswal, Edmund J S Sonuga-Barke, John Rotrosen, Lenard A. Adler, Michael P. Milham

Research output: Contribution to journalArticle

563 Citations (Scopus)

Abstract

Background: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. Methods: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. Results: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 × 10-11, corrected) and portions of posterior cingulate (p < .02, corrected). Conclusions: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.

Original languageEnglish (US)
Pages (from-to)332-337
Number of pages6
JournalBiological Psychiatry
Volume63
Issue number3
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

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Parietal Lobe
Gyrus Cinguli
Attention Deficit Disorder with Hyperactivity
Healthy Volunteers
Corpus Striatum
Prefrontal Cortex
Magnetic Resonance Imaging
Oxygen

Keywords

  • ADHD
  • anterior cingulate cortex
  • default-mode network
  • functional magnetic resonance imaging
  • posterior cingulate cortex
  • precuneus

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Cingulate-Precuneus Interactions : A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder. / Castellanos, F. Xavier; Margulies, Daniel S.; Kelly, Clare; Uddin, Lucina Q; Ghaffari, Manely; Kirsch, Andrew; Shaw, David; Shehzad, Zarrar; Di Martino, Adriana; Biswal, Bharat; Sonuga-Barke, Edmund J S; Rotrosen, John; Adler, Lenard A.; Milham, Michael P.

In: Biological Psychiatry, Vol. 63, No. 3, 01.02.2008, p. 332-337.

Research output: Contribution to journalArticle

Castellanos, FX, Margulies, DS, Kelly, C, Uddin, LQ, Ghaffari, M, Kirsch, A, Shaw, D, Shehzad, Z, Di Martino, A, Biswal, B, Sonuga-Barke, EJS, Rotrosen, J, Adler, LA & Milham, MP 2008, 'Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder', Biological Psychiatry, vol. 63, no. 3, pp. 332-337. https://doi.org/10.1016/j.biopsych.2007.06.025
Castellanos, F. Xavier ; Margulies, Daniel S. ; Kelly, Clare ; Uddin, Lucina Q ; Ghaffari, Manely ; Kirsch, Andrew ; Shaw, David ; Shehzad, Zarrar ; Di Martino, Adriana ; Biswal, Bharat ; Sonuga-Barke, Edmund J S ; Rotrosen, John ; Adler, Lenard A. ; Milham, Michael P. / Cingulate-Precuneus Interactions : A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder. In: Biological Psychiatry. 2008 ; Vol. 63, No. 3. pp. 332-337.
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AU - Kirsch, Andrew

AU - Shaw, David

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AU - Di Martino, Adriana

AU - Biswal, Bharat

AU - Sonuga-Barke, Edmund J S

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