Ciliary beat co-ordination by calcium

Andreas Schmid, Matthias A Salathe

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Motile cilia in the airway epithelium are the engine for mucociliary clearance, the mechanism responsible for cleaning the airways from inhaled particles. Human airway epithelial cilia appear to have a slow constitutive rate of beating, driven by inherent and spontaneous dynein ATPase activity. Additionally, cilia can increase their beating frequency by activation of several different control mechanisms. One of these controllers is calcium. Its intracellular concentration is regulated by purinergic and acetylcholine receptors. Besides the rate regulatory effect of calcium on ciliary beat, calcium is also involved in synchronizing the beat among cilia of one single cell as well as between cilia on different cells. This article gives an overview of the complex effects of calcium on the beating of motile cilia in the airways.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalBiology of the Cell
Volume103
Issue number4
DOIs
StatePublished - Apr 1 2011

Fingerprint

Cilia
Calcium
Mucociliary Clearance
Purinergic Receptors
Dyneins
Cholinergic Receptors
Epithelium

Keywords

  • Acetylcholine (Ach)
  • Calcium
  • Ciliary beat frequency (CBF)
  • Pannexin
  • Purinergic signalling
  • Synchronization

ASJC Scopus subject areas

  • Cell Biology

Cite this

Ciliary beat co-ordination by calcium. / Schmid, Andreas; Salathe, Matthias A.

In: Biology of the Cell, Vol. 103, No. 4, 01.04.2011, p. 159-169.

Research output: Contribution to journalArticle

Schmid, Andreas ; Salathe, Matthias A. / Ciliary beat co-ordination by calcium. In: Biology of the Cell. 2011 ; Vol. 103, No. 4. pp. 159-169.
@article{d294a53311e64200960901a9838d51f7,
title = "Ciliary beat co-ordination by calcium",
abstract = "Motile cilia in the airway epithelium are the engine for mucociliary clearance, the mechanism responsible for cleaning the airways from inhaled particles. Human airway epithelial cilia appear to have a slow constitutive rate of beating, driven by inherent and spontaneous dynein ATPase activity. Additionally, cilia can increase their beating frequency by activation of several different control mechanisms. One of these controllers is calcium. Its intracellular concentration is regulated by purinergic and acetylcholine receptors. Besides the rate regulatory effect of calcium on ciliary beat, calcium is also involved in synchronizing the beat among cilia of one single cell as well as between cilia on different cells. This article gives an overview of the complex effects of calcium on the beating of motile cilia in the airways.",
keywords = "Acetylcholine (Ach), Calcium, Ciliary beat frequency (CBF), Pannexin, Purinergic signalling, Synchronization",
author = "Andreas Schmid and Salathe, {Matthias A}",
year = "2011",
month = "4",
day = "1",
doi = "10.1042/BC20100120",
language = "English",
volume = "103",
pages = "159--169",
journal = "Biology of the Cell",
issn = "0248-4900",
publisher = "Portland Press Ltd.",
number = "4",

}

TY - JOUR

T1 - Ciliary beat co-ordination by calcium

AU - Schmid, Andreas

AU - Salathe, Matthias A

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Motile cilia in the airway epithelium are the engine for mucociliary clearance, the mechanism responsible for cleaning the airways from inhaled particles. Human airway epithelial cilia appear to have a slow constitutive rate of beating, driven by inherent and spontaneous dynein ATPase activity. Additionally, cilia can increase their beating frequency by activation of several different control mechanisms. One of these controllers is calcium. Its intracellular concentration is regulated by purinergic and acetylcholine receptors. Besides the rate regulatory effect of calcium on ciliary beat, calcium is also involved in synchronizing the beat among cilia of one single cell as well as between cilia on different cells. This article gives an overview of the complex effects of calcium on the beating of motile cilia in the airways.

AB - Motile cilia in the airway epithelium are the engine for mucociliary clearance, the mechanism responsible for cleaning the airways from inhaled particles. Human airway epithelial cilia appear to have a slow constitutive rate of beating, driven by inherent and spontaneous dynein ATPase activity. Additionally, cilia can increase their beating frequency by activation of several different control mechanisms. One of these controllers is calcium. Its intracellular concentration is regulated by purinergic and acetylcholine receptors. Besides the rate regulatory effect of calcium on ciliary beat, calcium is also involved in synchronizing the beat among cilia of one single cell as well as between cilia on different cells. This article gives an overview of the complex effects of calcium on the beating of motile cilia in the airways.

KW - Acetylcholine (Ach)

KW - Calcium

KW - Ciliary beat frequency (CBF)

KW - Pannexin

KW - Purinergic signalling

KW - Synchronization

UR - http://www.scopus.com/inward/record.url?scp=79952746347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952746347&partnerID=8YFLogxK

U2 - 10.1042/BC20100120

DO - 10.1042/BC20100120

M3 - Article

C2 - 21401526

AN - SCOPUS:79952746347

VL - 103

SP - 159

EP - 169

JO - Biology of the Cell

JF - Biology of the Cell

SN - 0248-4900

IS - 4

ER -