Abstract
A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3-day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1-day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly.
| Original language | English |
|---|---|
| Pages (from-to) | 544-547 |
| Number of pages | 4 |
| Journal | Annals of Neurology |
| Volume | 15 |
| Issue number | 6 |
| State | Published - Jan 1 1984 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Chronicity of hyponatremia as a factor in experimental myelinolysis. / Norenberg, Michael D; Papendick, R. E.
In: Annals of Neurology, Vol. 15, No. 6, 01.01.1984, p. 544-547.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronicity of hyponatremia as a factor in experimental myelinolysis
AU - Norenberg, Michael D
AU - Papendick, R. E.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3-day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1-day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly.
AB - A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3-day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1-day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021239548&partnerID=8YFLogxK
M3 - Article
VL - 15
SP - 544
EP - 547
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 6
ER -