Abstract
A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3-day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1-day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly.
Original language | English (US) |
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Pages (from-to) | 544-547 |
Number of pages | 4 |
Journal | Annals of neurology |
Volume | 15 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1984 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology