Chronicity of hyponatremia as a factor in experimental myelinolysis

Michael D. Norenberg, Rebecca E. Papendick

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3-day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1-day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalAnnals of neurology
Issue number6
StatePublished - Jun 1984

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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