Chronic venous insufficiency and venous leg ulceration

Isabel C. Valencia, Anna Falabella, Robert S. Kirsner, William H. Eaglstein

Research output: Contribution to journalArticlepeer-review

368 Scopus citations


Venous ulcers are the most common form of leg ulcers. Venous disease has a significant impact on quality of life and work productivity. In addition, the costs associated with the long-term care of these chronic wounds are substantial. Although the exact pathogenic steps leading from venous hypertension to venous ulceration remain unclear, several hypotheses have been developed to explain the development of venous ulceration. A better understanding of the current pathophysiology of venous ulceration has led to the development of new approaches in its management. New types of wound dressings, topical and systemic therapeutic agents, surgical modalities, bioengineered tissue, matrix materials, and growth factors are all novel therapeutic options that may be used in addition to the "gold standard," compression therapy, for venous ulcers. This review discusses current aspects of the epidemiology, pathophysiology, clinical presentation, diagnostic assessment, and current therapeutic options for chronic venous insufficiency and venous ulceration.

Original languageEnglish (US)
Pages (from-to)401-424
Number of pages24
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Dermatology


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