Chronic transfusion practice for children with sickle cell anaemia and stroke

Banu Aygun, Marsha A. McMurray, William H. Schultz, Janet L. Kwiatkowski, Lee Hilliard, Ofelia Alvarez, Matthew Heeney, Karen Kalinyak, Margaret T. Lee, Scott Miller, Ronald W. Helms, Russell E. Ware

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Chronic transfusions to maintain haemoglobin S (HbS) ≤30% are the mainstay of treatment for children with sickle cell anaemia (SCA) and previous stroke. This HbS target is often hard to maintain, however, and values achieved in current practice are unknown. In preparation for the Phase III Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) trial, we collected data on 295 children with SCA and stroke who received transfusions at 23 institutions. The overall average pre-transfusion %HbS was 35 ± 11% (institutional range 22-51%). Receiving scheduled transfusions on time was the most predictive variable for maintaining HbS at the ≤30% goal.

Original languageEnglish (US)
Pages (from-to)524-528
Number of pages5
JournalBritish Journal of Haematology
Issue number4
StatePublished - May 2009


  • %Hb S level
  • Sickle cell anaemia
  • Stroke
  • Transfusion

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Chronic transfusion practice for children with sickle cell anaemia and stroke'. Together they form a unique fingerprint.

Cite this