Chronic systemic administration of tumor necrosis factor alpha and HIV gp120: Effects on adult rodent brain and blood-brain barrier

C. K. Petito, B. Adkins, K. Tracey, B. Roberts, J. Torres-Munoz, M. McCarthy, C. Czeisler

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Since tumor necrosis factor alpha (TNF-α) and HIV gp120 glycoprotein are both neurotoxic, the possibility that systemic sources of these two agents mediate AIDS-associated blood-brain barrier (BBB) breakdown and brain damage was tested in two murine models: (1) intramuscular implantation of a TNF-α-transfected tumor in nu/nu mice and (2) daily subcutaneous injections of HIV gp120 in BALB/c mice. The BBB remained intact; brain damage was not found, and apoptotic cell numbers did not increase. These results show that normal adult brain and BBB is unaffected by exposure to TNF-α or HIV gp120 and suggest that severity of brain disease is not directly affected by systemic levels of these compounds.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalJournal of neurovirology
Volume5
Issue number3
StatePublished - Jul 27 1999

Keywords

  • AIDS
  • Central nervous system
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

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