Chronic systemic administration of tumor necrosis factor alpha and HIV gp120: Effects on adult rodent brain and blood-brain barrier

Carol Petito, Rebecca D Adkins, K. Tracey, B. Roberts, J. Torres-Munoz, Micheline McCarthy, C. Czeisler

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Since tumor necrosis factor alpha (TNF-α) and HIV gp120 glycoprotein are both neurotoxic, the possibility that systemic sources of these two agents mediate AIDS-associated blood-brain barrier (BBB) breakdown and brain damage was tested in two murine models: (1) intramuscular implantation of a TNF-α-transfected tumor in nu/nu mice and (2) daily subcutaneous injections of HIV gp120 in BALB/c mice. The BBB remained intact; brain damage was not found, and apoptotic cell numbers did not increase. These results show that normal adult brain and BBB is unaffected by exposure to TNF-α or HIV gp120 and suggest that severity of brain disease is not directly affected by systemic levels of these compounds.

Original languageEnglish
Pages (from-to)314-318
Number of pages5
JournalJournal of NeuroVirology
Volume5
Issue number3
StatePublished - Jul 27 1999

Fingerprint

HIV Envelope Protein gp120
Blood-Brain Barrier
Rodentia
Tumor Necrosis Factor-alpha
Brain
Brain Diseases
Subcutaneous Injections
Glycoproteins
Acquired Immunodeficiency Syndrome
Cell Count
Neoplasms

Keywords

  • AIDS
  • Central nervous system
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Chronic systemic administration of tumor necrosis factor alpha and HIV gp120 : Effects on adult rodent brain and blood-brain barrier. / Petito, Carol; Adkins, Rebecca D; Tracey, K.; Roberts, B.; Torres-Munoz, J.; McCarthy, Micheline; Czeisler, C.

In: Journal of NeuroVirology, Vol. 5, No. 3, 27.07.1999, p. 314-318.

Research output: Contribution to journalArticle

Petito, C, Adkins, RD, Tracey, K, Roberts, B, Torres-Munoz, J, McCarthy, M & Czeisler, C 1999, 'Chronic systemic administration of tumor necrosis factor alpha and HIV gp120: Effects on adult rodent brain and blood-brain barrier', Journal of NeuroVirology, vol. 5, no. 3, pp. 314-318.
Petito, Carol ; Adkins, Rebecca D ; Tracey, K. ; Roberts, B. ; Torres-Munoz, J. ; McCarthy, Micheline ; Czeisler, C. / Chronic systemic administration of tumor necrosis factor alpha and HIV gp120 : Effects on adult rodent brain and blood-brain barrier. In: Journal of NeuroVirology. 1999 ; Vol. 5, No. 3. pp. 314-318.
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