Abstract
Since tumor necrosis factor alpha (TNF-α) and HIV gp120 glycoprotein are both neurotoxic, the possibility that systemic sources of these two agents mediate AIDS-associated blood-brain barrier (BBB) breakdown and brain damage was tested in two murine models: (1) intramuscular implantation of a TNF-α-transfected tumor in nu/nu mice and (2) daily subcutaneous injections of HIV gp120 in BALB/c mice. The BBB remained intact; brain damage was not found, and apoptotic cell numbers did not increase. These results show that normal adult brain and BBB is unaffected by exposure to TNF-α or HIV gp120 and suggest that severity of brain disease is not directly affected by systemic levels of these compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 314-318 |
| Number of pages | 5 |
| Journal | Journal of NeuroVirology |
| Volume | 5 |
| Issue number | 3 |
| State | Published - Jul 27 1999 |
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Keywords
- AIDS
- Central nervous system
- Human immunodeficiency virus
ASJC Scopus subject areas
- Virology
- Clinical Neurology
Cite this
Chronic systemic administration of tumor necrosis factor alpha and HIV gp120 : Effects on adult rodent brain and blood-brain barrier. / Petito, Carol; Adkins, Rebecca D; Tracey, K.; Roberts, B.; Torres-Munoz, J.; McCarthy, Micheline; Czeisler, C.
In: Journal of NeuroVirology, Vol. 5, No. 3, 27.07.1999, p. 314-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic systemic administration of tumor necrosis factor alpha and HIV gp120
T2 - Effects on adult rodent brain and blood-brain barrier
AU - Petito, Carol
AU - Adkins, Rebecca D
AU - Tracey, K.
AU - Roberts, B.
AU - Torres-Munoz, J.
AU - McCarthy, Micheline
AU - Czeisler, C.
PY - 1999/7/27
Y1 - 1999/7/27
N2 - Since tumor necrosis factor alpha (TNF-α) and HIV gp120 glycoprotein are both neurotoxic, the possibility that systemic sources of these two agents mediate AIDS-associated blood-brain barrier (BBB) breakdown and brain damage was tested in two murine models: (1) intramuscular implantation of a TNF-α-transfected tumor in nu/nu mice and (2) daily subcutaneous injections of HIV gp120 in BALB/c mice. The BBB remained intact; brain damage was not found, and apoptotic cell numbers did not increase. These results show that normal adult brain and BBB is unaffected by exposure to TNF-α or HIV gp120 and suggest that severity of brain disease is not directly affected by systemic levels of these compounds.
AB - Since tumor necrosis factor alpha (TNF-α) and HIV gp120 glycoprotein are both neurotoxic, the possibility that systemic sources of these two agents mediate AIDS-associated blood-brain barrier (BBB) breakdown and brain damage was tested in two murine models: (1) intramuscular implantation of a TNF-α-transfected tumor in nu/nu mice and (2) daily subcutaneous injections of HIV gp120 in BALB/c mice. The BBB remained intact; brain damage was not found, and apoptotic cell numbers did not increase. These results show that normal adult brain and BBB is unaffected by exposure to TNF-α or HIV gp120 and suggest that severity of brain disease is not directly affected by systemic levels of these compounds.
KW - AIDS
KW - Central nervous system
KW - Human immunodeficiency virus
UR - http://www.scopus.com/inward/record.url?scp=0032787879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032787879&partnerID=8YFLogxK
M3 - Article
C2 - 10414522
AN - SCOPUS:0032787879
VL - 5
SP - 314
EP - 318
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - 3
ER -