Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice

Roberta M. Lassance-Soares, Subeena Sood, Nabarun Chakraborty, Sunny Jhamnani, Nima Aghili, Hajra Nashin, Rasha Hammamieh, Marti Jett, Stephen E. Epstein, Mary Susan Burnett

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor’s cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.

Original languageEnglish (US)
Pages (from-to)749-755
Number of pages7
JournalJournal of cardiovascular translational research
Issue number8
StatePublished - Nov 15 2014
Externally publishedYes


  • Blood flow
  • Chronic stress
  • Collaterals
  • Femoral artery ligation
  • Flow recovery
  • Hind limb
  • Ischemia
  • Mouse

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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