Chronic respiratory failure in neonates

Research output: Chapter in Book/Report/Conference proceedingChapter


The original publication on bronchopulmonary dysplasia (BPD) by Northway and collaborators described a group of preterm infants who after prolonged mechanical ventilation developed chronic respiratory failure and characteristic radiographic findings (Northway et al. 1967). The lung damage was attributed primarily to the use of aggressive positive-pressure ventilation and high inspired oxygen concentrations. Today, with the widespread use of antenatal corticosteroids and the use of postnatal surfactant and less aggressive mechanical ventilation, this severe form of BPD has been replaced by a milder form that presents in the more immature infants who frequently have only mild initial respiratory disease (Charafeddine et al. 1999; Parker et al. 1992; Rojas et al. 1995). Therefore, these infants are not exposed to the very high airway pressures or oxygen concentrations, the two main factors in the pathogenesis of the original form of BPD. This milder form of the disease has been described as “New BPD.” This new presentation has created some inconsistencies and confusion in the definition and the diagnostic criteria of BPD (Bancalari et al. 2003).

Original languageEnglish (US)
Title of host publicationPediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice
PublisherSpringer Berlin Heidelberg
Number of pages11
ISBN (Print)9783642012198, 9783642012181
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)


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