Chronic renal failure in children: Analysis of main causes and deterioration rate in 81 children

G. Zilleruelo, J. Andia, H. M. Gorman, J. Strauss

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Cause of chronic renal failure (CRF), age at clinical onset, and deterioration rate were studied in 81 unselected children 2 months to 18 years old who were referred to UM-JMH during a six-year period. Obstructive uropathies caused 42%, glomerulopathies 27%, renal hypoplasia 15%, and hereditary and vascular nephropathies 8%. Age at clinical onset of CRF was significantly lower in patients with obstructive uropathies (2.8 years) and renal hypoplasias (2.4 years) than in glomerulopathies (10.7 years). Deterioration rate correlated with cause of CRF; it was more rapid in primary glomerulopathies (4.1 years) and renal hypoplasias (4.2 years) than in obstructive uropathies (6.7 years). Within the six-year period, half the patients studied reached end-stage renal disease (ESRD). Final outcome did not seem to be modified significantly by corrective procedures. These findings suggest that prior efforts should be directed toward identification of the etiopathogenesis of congenital nephropathies to prevent occurrence of CRF.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalInternational Journal of Pediatric Nephrology
Volume1
Issue number1
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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