Chronic recordings from the rat spinal cord descending tracts with microwires

Abhishek Prasad, Mesut Sahin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages2993-2996
Number of pages4
DOIs
StatePublished - 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: Aug 30 2011Sep 3 2011

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period8/30/119/3/11

Fingerprint

Rats
Spinal Cord
Electrodes
Long Evans Rats
Feasibility Studies
Signal-To-Noise Ratio
Hand Strength
Analysis of variance (ANOVA)
Signal to noise ratio
Analysis of Variance
Animals
Tissue
Food

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Prasad, A., & Sahin, M. (2011). Chronic recordings from the rat spinal cord descending tracts with microwires. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 2993-2996). [6090821] https://doi.org/10.1109/IEMBS.2011.6090821

Chronic recordings from the rat spinal cord descending tracts with microwires. / Prasad, Abhishek; Sahin, Mesut.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. p. 2993-2996 6090821.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Prasad, A & Sahin, M 2011, Chronic recordings from the rat spinal cord descending tracts with microwires. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6090821, pp. 2993-2996, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6090821
Prasad A, Sahin M. Chronic recordings from the rat spinal cord descending tracts with microwires. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. p. 2993-2996. 6090821 https://doi.org/10.1109/IEMBS.2011.6090821
Prasad, Abhishek ; Sahin, Mesut. / Chronic recordings from the rat spinal cord descending tracts with microwires. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. pp. 2993-2996
@inproceedings{e35cdd3cc4ec472dbe36bc936bb2de69,
title = "Chronic recordings from the rat spinal cord descending tracts with microwires",
abstract = "This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.",
author = "Abhishek Prasad and Mesut Sahin",
year = "2011",
doi = "10.1109/IEMBS.2011.6090821",
language = "English (US)",
isbn = "9781424441211",
pages = "2993--2996",
booktitle = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

}

TY - GEN

T1 - Chronic recordings from the rat spinal cord descending tracts with microwires

AU - Prasad, Abhishek

AU - Sahin, Mesut

PY - 2011

Y1 - 2011

N2 - This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.

AB - This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.

UR - http://www.scopus.com/inward/record.url?scp=84055222550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84055222550&partnerID=8YFLogxK

U2 - 10.1109/IEMBS.2011.6090821

DO - 10.1109/IEMBS.2011.6090821

M3 - Conference contribution

SN - 9781424441211

SP - 2993

EP - 2996

BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

ER -