Chronic Pruritus and Connective Tissue Disorders: Review, Gaps, and Future Directions

Jessica Sue Haber, Rodrigo Valdes-Rodriguez, Gil Yosipovitch

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch. It is important to better understand the pathophysiology of chronic itch in these conditions, as this information might provide a fuller understanding of the pathogenesis of the diseases in general and lead to the development of more specific treatments for connective tissue diseases in patients with chronic itch. We present a review of the literature on what is known about the prevalence, possible pathophysiology, and effect on quality of life of chronic itch in patients with scleroderma, Sjögren’s syndrome, dermatomyositis, systemic lupus erythematosus, cutaneous lupus erythematosus, and mixed connective tissue disease.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalAmerican Journal of Clinical Dermatology
Issue number5
StatePublished - Oct 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Chronic Pruritus and Connective Tissue Disorders: Review, Gaps, and Future Directions'. Together they form a unique fingerprint.

Cite this