Chronic pruritus

A paraneoplastic sign

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Chronic itch could be a presenting sign of malignancy. Pruritus of lymphoma is the common prototype of paraneoplastic itch and can precede other clinical signs by weeks and months. Paraneoplastic pruritus has also been associated with solid tumors and is an important clinical symptom in paraneoplastic skin diseases such as erythroderma, Grovers disease, malignant acanthosis nigricans, generalized granuloma annulare, Bazex syndrome, and dermatomyositis. In any case with high index of suspicion a thorough work-up is required. This review highlights the association between itch and malignancy and presents new findings related to pathophysiological mechanisms and the treatment of itch associated with malignancy. Combinative therapies reducing itch sensitization and transmission using selective serotonin and neuroepinephrine reuptake inhibitors, Kappa opioids, and neuroleptics are of prime importance in reducing this bothersome symptom.

Original languageEnglish (US)
Pages (from-to)590-596
Number of pages7
JournalDermatologic Therapy
Volume23
Issue number6
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

Pruritus
Neoplasms
Granuloma Annulare
Acanthosis Nigricans
Exfoliative Dermatitis
Dermatomyositis
Serotonin Uptake Inhibitors
Skin Diseases
Opioid Analgesics
Antipsychotic Agents
Lymphoma
Therapeutics

Keywords

  • itch pathophysiology
  • kappa opioids
  • neuroleptics
  • paraneoplastic itch

ASJC Scopus subject areas

  • Dermatology

Cite this

Chronic pruritus : A paraneoplastic sign. / Yosipovitch, Gil.

In: Dermatologic Therapy, Vol. 23, No. 6, 01.11.2010, p. 590-596.

Research output: Contribution to journalReview article

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