Chronic prurigo of nodular type: A review

Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remains unclear. Current state-of-the-art therapy for PN consists of topical steroids, capsaicin, calcineurin inhibitors, ultraviolet (UV) therapy, systemic administration of gabapentinoids, μ-opioid receptor antagonists, antidepressants or immunosuppressants. Novel treatment concepts, such as inhibitors of neurokinin-1, opioid and interleukin-31 receptors, have been developed and are currently being clinically tested.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalActa Dermato-Venereologica
Volume98
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Prurigo
Pruritus
Ultraviolet Therapy
Interleukin Receptors
Art Therapy
Narcotic Antagonists
Capsaicin
Immunosuppressive Agents
Opioid Analgesics
Antidepressive Agents
Psychiatry
Steroids

Keywords

  • Chronic scratch lesions
  • Hyde’s prurigo
  • Interleukin-31
  • Itch
  • Neurokinin-1
  • Prurigo nodularis
  • Pruritus

ASJC Scopus subject areas

  • Dermatology

Cite this

Zeidler, C., Tsianakas, A., Pereira, M., Ständer, H., Yosipovitch, G., & Ständer, S. (2018). Chronic prurigo of nodular type: A review. Acta Dermato-Venereologica, 98(2), 173-179. https://doi.org/10.2340/00015555-2774

Chronic prurigo of nodular type : A review. / Zeidler, Claudia; Tsianakas, Athanasios; Pereira, Manuel; Ständer, Hartmut; Yosipovitch, Gil; Ständer, Sonja.

In: Acta Dermato-Venereologica, Vol. 98, No. 2, 01.02.2018, p. 173-179.

Research output: Contribution to journalReview article

Zeidler, C, Tsianakas, A, Pereira, M, Ständer, H, Yosipovitch, G & Ständer, S 2018, 'Chronic prurigo of nodular type: A review', Acta Dermato-Venereologica, vol. 98, no. 2, pp. 173-179. https://doi.org/10.2340/00015555-2774
Zeidler C, Tsianakas A, Pereira M, Ständer H, Yosipovitch G, Ständer S. Chronic prurigo of nodular type: A review. Acta Dermato-Venereologica. 2018 Feb 1;98(2):173-179. https://doi.org/10.2340/00015555-2774
Zeidler, Claudia ; Tsianakas, Athanasios ; Pereira, Manuel ; Ständer, Hartmut ; Yosipovitch, Gil ; Ständer, Sonja. / Chronic prurigo of nodular type : A review. In: Acta Dermato-Venereologica. 2018 ; Vol. 98, No. 2. pp. 173-179.
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