Chronic progressive CNS histoplasmosis presenting in childhood

Response to fluconazole therapy

Ignacio V. Rivera, Richard G. Curless, Fernando J. Indacochea, Gwendolyn B Scott

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

An 18-year-old Hispanic female developed symptoms of a Histoplasma capsulatum infection at 9 1 2 years of age. Initial problems of ataxia and hydrocephalus were followed by seizures and a cranial nerve palsy which developed over several years. T1-weighted cranial magnetic resonance imaging studies revealed numerous high-signal lesions; subsequently, signs of multisystem dissemination developed. Treatment included ventriculoperitoneal shunting, corticosteroids, amphotericin B, and a new antifungal agent, fluconazole, which was responsible for marked improvement.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalPediatric Neurology
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1992

Fingerprint

Histoplasma
Cranial Nerve Diseases
Histoplasmosis
Fluconazole
Antifungal Agents
Amphotericin B
Ataxia
Hydrocephalus
Hispanic Americans
Adrenal Cortex Hormones
Seizures
Magnetic Resonance Imaging
Infection
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Chronic progressive CNS histoplasmosis presenting in childhood : Response to fluconazole therapy. / Rivera, Ignacio V.; Curless, Richard G.; Indacochea, Fernando J.; Scott, Gwendolyn B.

In: Pediatric Neurology, Vol. 8, No. 2, 01.01.1992, p. 151-153.

Research output: Contribution to journalArticle

Rivera, Ignacio V. ; Curless, Richard G. ; Indacochea, Fernando J. ; Scott, Gwendolyn B. / Chronic progressive CNS histoplasmosis presenting in childhood : Response to fluconazole therapy. In: Pediatric Neurology. 1992 ; Vol. 8, No. 2. pp. 151-153.
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