Chronic progressive CNS histoplasmosis presenting in childhood: Response to fluconazole therapy

Ignacio V. Rivera, Richard G. Curless, Fernando J. Indacochea, Gwen B. Scott

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

An 18-year-old Hispanic female developed symptoms of a Histoplasma capsulatum infection at 9 1 2 years of age. Initial problems of ataxia and hydrocephalus were followed by seizures and a cranial nerve palsy which developed over several years. T1-weighted cranial magnetic resonance imaging studies revealed numerous high-signal lesions; subsequently, signs of multisystem dissemination developed. Treatment included ventriculoperitoneal shunting, corticosteroids, amphotericin B, and a new antifungal agent, fluconazole, which was responsible for marked improvement.

Original languageEnglish (US)
Pages (from-to)151-153
Number of pages3
JournalPediatric Neurology
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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