Chronic, oral aluminum administration to rats: Cognition and cholinergic parameters

Donald J. Connor; Richard S. Jope; Lindy E. Harrell

doi:10.1016/0091-3057(88)90375-9

Chronic, oral aluminum administration to rats: Cognition and cholinergic parameters

Donald J. Connor, Richard S. Jope, Lindy E. Harrell

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for thirty days resulted in an impairment of both consolidation and extinction of a passive avoidance task. No impairment of performance was observed on an active avoidance task, radial arm maze or open field activity measure. Biochemical analysis indicated a slight (<10%) but significant increase in hippocampal muscarinic receptor number after aluminum treatment as determined by tritiated quinuclidinyl benzilate (³H-QNB) binding. No changes were found in choline acetyltransferase (ChAT) activity, phosphoinositide hydrolysis, ³H-QNB binding in the cortex or tritiated pirenzepine (³H-PZ) binding in the hippocampus or cortex. These results indicate that cholinergic degeneration was not the cause of the observed cognitive impairments.

Original language	English (US)
Pages (from-to)	467-474
Number of pages	8
Journal	Pharmacology, Biochemistry and Behavior
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(88)90375-9
State	Published - Oct 1988
Externally published	Yes

Keywords

Active avoidance
Aluminum
Behavior
Muscarinic
Neurotoxin
Passive avoidance
Phosphoinositides
Radial arm maze
Rats

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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title = "Chronic, oral aluminum administration to rats: Cognition and cholinergic parameters",

abstract = "Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for thirty days resulted in an impairment of both consolidation and extinction of a passive avoidance task. No impairment of performance was observed on an active avoidance task, radial arm maze or open field activity measure. Biochemical analysis indicated a slight (<10%) but significant increase in hippocampal muscarinic receptor number after aluminum treatment as determined by tritiated quinuclidinyl benzilate (3H-QNB) binding. No changes were found in choline acetyltransferase (ChAT) activity, phosphoinositide hydrolysis, 3H-QNB binding in the cortex or tritiated pirenzepine (3H-PZ) binding in the hippocampus or cortex. These results indicate that cholinergic degeneration was not the cause of the observed cognitive impairments.",

keywords = "Active avoidance, Aluminum, Behavior, Muscarinic, Neurotoxin, Passive avoidance, Phosphoinositides, Radial arm maze, Rats",

author = "Connor, {Donald J.} and Jope, {Richard S.} and Harrell, {Lindy E.}",

note = "Funding Information: The authors thank Kathleen Lally, Dee S. Parsons and Andrea Peagler for technical assistance and Diane Lee for preparing the manuscript. This investigation was supported by a grant from the NIA AG04719 (R.S.J.), NIMH 5R01-MH38518 (L.E.H.) and by a grant from the Alzheimer's Disease and Related Disorder Association (L.E.H.).",

year = "1988",

month = oct,

doi = "10.1016/0091-3057(88)90375-9",

language = "English (US)",

volume = "31",

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AU - Jope, Richard S.

AU - Harrell, Lindy E.

N1 - Funding Information: The authors thank Kathleen Lally, Dee S. Parsons and Andrea Peagler for technical assistance and Diane Lee for preparing the manuscript. This investigation was supported by a grant from the NIA AG04719 (R.S.J.), NIMH 5R01-MH38518 (L.E.H.) and by a grant from the Alzheimer's Disease and Related Disorder Association (L.E.H.).

PY - 1988/10

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N2 - Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for thirty days resulted in an impairment of both consolidation and extinction of a passive avoidance task. No impairment of performance was observed on an active avoidance task, radial arm maze or open field activity measure. Biochemical analysis indicated a slight (<10%) but significant increase in hippocampal muscarinic receptor number after aluminum treatment as determined by tritiated quinuclidinyl benzilate (3H-QNB) binding. No changes were found in choline acetyltransferase (ChAT) activity, phosphoinositide hydrolysis, 3H-QNB binding in the cortex or tritiated pirenzepine (3H-PZ) binding in the hippocampus or cortex. These results indicate that cholinergic degeneration was not the cause of the observed cognitive impairments.

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