TY - JOUR
T1 - Chronic multifocal retinal infiltrates in patients infected with human immunodeficiency virus
AU - Levinson, Ralph D.
AU - Vann, Robin
AU - Davis, Janet L.
AU - Friedberg, Dorothy N.
AU - Tufail, Adnan
AU - Terry, Brian T.
AU - Lindley, Janette I.
AU - Holland, Gary N.
N1 - Funding Information:
From the UCLA Ocular Inflammatory Disease Center, the Jules Stein Eye Institute, and Department of Ophthalmology, University of California, Los Angeles, School of Medicine, Los Angeles, California (Drs Levmson, Tufail, and Holland); the Bascom Palmer Eye Institute and Department of Ophthalmology, University of Miami School of Medicine, Miatm, Florida (Drs Vann and Davis); the Department of Ophthalmology, New York University School of Medicme, New York, New York (Dr Friedberg); the Community Eye Medical Group, Pasadena, California (Dr Terry); and the Ocular AIDS Group, St Paul’s Hospital, Vancouver, British Columbia, Canada (Dr Lindley). Supported in part by the Elizabeth Taylor AIDS Foundation, Los Angeles, California; Research to Prevent Blindness, Inc, New York, New York; and the Ski&all Foundation, Los Angeles, California (Dr Holland). Dr Holland is a recipient of a Research to Prevent Blindness, Inc, Lew R. Wasserman Merit Award.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1998/3
Y1 - 1998/3
N2 - PURPOSE: To describe the clinical features of a disorder characterized by chronic multifocal retinal infiltrates and uveitis in individuals with human immunodeficiency virus (HIV) disease. METHODS: We reviewed the medical records of HIV-infected patients with multifocal retinal infiltrates of unknown cause seen by investigators at four institutions. The following data were collected: demographic characteristics, presenting signs and symptoms, laboratory test results, and course of disease. RESULTS: We identified 26 HIV-infected patients (50 involved eyes) with this syndrome. Median CD4+ T- lymphocyte count at presentation was 272 per μl (range, 7 to 2,118 per μl). The most common presenting symptom was floaters. Median visual acuity of involved eyes at presentation was 20/20 (range, 20/15 to 20/100) and remained stable (median, 20/20; range, 20/15 to 20/70) after a median follow-up period of 9 months (range, 0 to 110 months). Typical retinal lesions were gray- white or yellow, irregular in shape, and less than 200 μm in greatest dimension. All were located in the midperiphery or anterior retina and enlarged slowly or remained static in size. Mild to moderate anterior chamber or vitreous humor inflammatory cells were present in 47 of 50 eyes (26 of 26 patients). Retinal lesions possibly responded to zidovudine but not to acyclovir or ganciclovir. Anterior chamber and vitreous humor inflammatory reactions responded to topical or periocular injections of corticosteroid. CONCLUSIONS: Uveitis with chronic multifocal retinal infiltrates is a distinct clinical entity of unknown cause that occurs in HIV-infected patients. Retinal lesions may respond to antiretroviral therapy. Visual prognosis is good.
AB - PURPOSE: To describe the clinical features of a disorder characterized by chronic multifocal retinal infiltrates and uveitis in individuals with human immunodeficiency virus (HIV) disease. METHODS: We reviewed the medical records of HIV-infected patients with multifocal retinal infiltrates of unknown cause seen by investigators at four institutions. The following data were collected: demographic characteristics, presenting signs and symptoms, laboratory test results, and course of disease. RESULTS: We identified 26 HIV-infected patients (50 involved eyes) with this syndrome. Median CD4+ T- lymphocyte count at presentation was 272 per μl (range, 7 to 2,118 per μl). The most common presenting symptom was floaters. Median visual acuity of involved eyes at presentation was 20/20 (range, 20/15 to 20/100) and remained stable (median, 20/20; range, 20/15 to 20/70) after a median follow-up period of 9 months (range, 0 to 110 months). Typical retinal lesions were gray- white or yellow, irregular in shape, and less than 200 μm in greatest dimension. All were located in the midperiphery or anterior retina and enlarged slowly or remained static in size. Mild to moderate anterior chamber or vitreous humor inflammatory cells were present in 47 of 50 eyes (26 of 26 patients). Retinal lesions possibly responded to zidovudine but not to acyclovir or ganciclovir. Anterior chamber and vitreous humor inflammatory reactions responded to topical or periocular injections of corticosteroid. CONCLUSIONS: Uveitis with chronic multifocal retinal infiltrates is a distinct clinical entity of unknown cause that occurs in HIV-infected patients. Retinal lesions may respond to antiretroviral therapy. Visual prognosis is good.
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U2 - 10.1016/S0002-9394(99)80137-8
DO - 10.1016/S0002-9394(99)80137-8
M3 - Article
C2 - 9512148
AN - SCOPUS:17944394420
VL - 125
SP - 312
EP - 324
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 3
ER -
