Chronic measles encephalitis in mice

Kottil W Rammohan, D. E. McFarlin, H. F. McFarland

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The intracerebral inoculation of hamster neurotropic measles virus produces a fatal acute encephalopathy in the majority of weanling BALB/c mice. The few survivors remain healthy indefinitely. In contrast, weanling SJL/J mice are relatively resistant to acute encephalopathy, and about one-third of the survivors predictably develop a chronic encephalitis many weeks after inoculation. This later illness is characterized clinically by wasting, lethargy, seizures, or focal paralysis, usually culminating in death. Pathologically, a considerable brain inflammatory response occurs in association with abundant measles viral antigen. Viral antigen and inflammation were demonstrable predominantly in the limbic system but were also present in the cerebellum and brain stem. Antibody to measles virus was readily demonstrated in all animals with chronic encephalitis. This report constitutes the first description of chronic measles encephalitis in an inbred host.

Original languageEnglish
Pages (from-to)608-613
Number of pages6
JournalJournal of Infectious Diseases
Volume142
Issue number4
StatePublished - Dec 1 1980
Externally publishedYes

Fingerprint

Measles
Encephalitis
Measles virus
Viral Antigens
Brain Diseases
Limbic System
Lethargy
Paralysis
Cricetinae
Cerebellum
Brain Stem
Seizures
Inflammation
Antibodies
Brain

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Rammohan, K. W., McFarlin, D. E., & McFarland, H. F. (1980). Chronic measles encephalitis in mice. Journal of Infectious Diseases, 142(4), 608-613.

Chronic measles encephalitis in mice. / Rammohan, Kottil W; McFarlin, D. E.; McFarland, H. F.

In: Journal of Infectious Diseases, Vol. 142, No. 4, 01.12.1980, p. 608-613.

Research output: Contribution to journalArticle

Rammohan, KW, McFarlin, DE & McFarland, HF 1980, 'Chronic measles encephalitis in mice', Journal of Infectious Diseases, vol. 142, no. 4, pp. 608-613.
Rammohan KW, McFarlin DE, McFarland HF. Chronic measles encephalitis in mice. Journal of Infectious Diseases. 1980 Dec 1;142(4):608-613.
Rammohan, Kottil W ; McFarlin, D. E. ; McFarland, H. F. / Chronic measles encephalitis in mice. In: Journal of Infectious Diseases. 1980 ; Vol. 142, No. 4. pp. 608-613.
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