Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features

Yang O. Huh, Carmen D. Schweighofer, Rhett P. Ketterling, Ryan A. Knudson, Francisco Vega, Ji E. Kim, Rajyalakshmi Luthra, Michael J. Keating, L. Jeffrey Medeiros, Lynne V. Abruzzo

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The t(14;19)(q32;q13) involving the IGH@ and BCL3 loci is an infrequent cytogenetic abnormality detected in B-cell malignancies. We describe the clinicopathologic, cytogenetic, and molecular genetic characteristics of 14 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with t(14;19)(q32;q13). All patients (10 men and 4 women) had lymphocytosis; 10 had lymphadenopathy. Blood and bone marrow lymphocytes were predominantly small, but cytologically and immunophenotypically atypical. In all cases, t(14;19) was found in the neoplastic stem line; it was the sole abnormality in 4. Ten cases showed additional cytogenetic abnormalities, including trisomy 12 in 9 and complex karyotypes in 7. Fluorescence in situ hybridization demonstrated IGH@/BCL3 fusion gene in all cases. In all cases, the IGHV genes were unmutated, but only 7 expressed ZAP70. Seven cases preferentially used IGHV4-39. Our results indicate that t(14;19)(q32;q13) identifies a subset of CLL/SLL with distinctive clinicopathologic and genetic features. Furthermore, t(14;19) may represent an early, possibly primary, genetic event.

Original languageEnglish (US)
Pages (from-to)686-696
Number of pages11
JournalAmerican journal of clinical pathology
Volume135
Issue number5
DOIs
StatePublished - May 1 2011
Externally publishedYes

Keywords

  • Atypical morphology
  • BCL3
  • Chronic lymphocytic leukemia
  • IGHV somatic mutation
  • t(14;19)(q32;q13)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Huh, Y. O., Schweighofer, C. D., Ketterling, R. P., Knudson, R. A., Vega, F., Kim, J. E., Luthra, R., Keating, M. J., Medeiros, L. J., & Abruzzo, L. V. (2011). Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features. American journal of clinical pathology, 135(5), 686-696. https://doi.org/10.1309/AJCPOEFP3SLX6HXJ