Chronic kidney disease stages 3-5 and cardiovascular disease in the veterans affairs population

Debasish Banerjee, Gabriel Contreras, Isabel Jaraba, Decio Carvalho, Luis Ortega, Cristiane Carvalho, Candido Pezon, Stephen P. Rosenthal, Norman La Rosa, Nuripama Vemuri, Gautam Cherla, Nilay Nahar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aim: Cardiovascular complications are common in patients with chronic kidney disease in the general population. The study aims to investigate the prevalence and prognosis of CKD stages 3-5 in the veterans affairs (VA) population, which is sicker with more co-morbid conditions. Methods: In this case-controlled study of 6,432 men the associations of risk factors with CKD and its risk of mortality were estimated using, primarily, logistic regression analysis. Results: The 1,045 (16.2%) patients with CKD stages 3-5 were older (72 ± 10 vs. 59 ± 13 years P < 0.0001) with more hypertension (53.6 vs. 39.6%, P < 0.0001), diabetes (24.9 vs. 19.8%, P < 0.0002), and CVD (35.3 vs. 17.8%, P < 0.0001) at baseline. Age ≤65 years (odds ratio [95% CI]) (4.95 [4.22-5.82]), hypertension (1.56 [1.34-1.79]), diabetes mellitus (1.21 [1.03-1.43]), CVD (1.71 [1.47-2.00]), and White not Hispanic (1.57 [1.32-1.85]) were independently associated with CKD. The prevalence of CVD at baseline increased with decreasing renal function. Old age (1.98 [1.66-2.35]), CKD (1.94 [1.61-2.33], CVD (1.46 [1.23-1.74]) and tobacco use (1.91 [1.05-3.47]) were independently associated with the 750 (11.7%) deaths. Conclusion: Among veterans, traditional cardiovascular risk factors, CVD, and CKD are highly prevalent. CKD is associated with increased risk of baseline CVD and follow-up mortality.

Original languageEnglish
Pages (from-to)443-451
Number of pages9
JournalInternational Urology and Nephrology
Volume41
Issue number2
DOIs
StatePublished - Jan 2 2009

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Veterans
Chronic Renal Insufficiency
Cardiovascular Diseases
Hypertension
Mortality
Tobacco Use
Hispanic Americans
Population
Diabetes Mellitus
Logistic Models
Odds Ratio
Regression Analysis
Kidney

Keywords

  • Cardiovascular disease
  • Chronic kidney disease
  • Hypertension
  • Mortality
  • Risk factors

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Chronic kidney disease stages 3-5 and cardiovascular disease in the veterans affairs population. / Banerjee, Debasish; Contreras, Gabriel; Jaraba, Isabel; Carvalho, Decio; Ortega, Luis; Carvalho, Cristiane; Pezon, Candido; Rosenthal, Stephen P.; La Rosa, Norman; Vemuri, Nuripama; Cherla, Gautam; Nahar, Nilay.

In: International Urology and Nephrology, Vol. 41, No. 2, 02.01.2009, p. 443-451.

Research output: Contribution to journalArticle

Banerjee, D, Contreras, G, Jaraba, I, Carvalho, D, Ortega, L, Carvalho, C, Pezon, C, Rosenthal, SP, La Rosa, N, Vemuri, N, Cherla, G & Nahar, N 2009, 'Chronic kidney disease stages 3-5 and cardiovascular disease in the veterans affairs population', International Urology and Nephrology, vol. 41, no. 2, pp. 443-451. https://doi.org/10.1007/s11255-008-9514-9
Banerjee, Debasish ; Contreras, Gabriel ; Jaraba, Isabel ; Carvalho, Decio ; Ortega, Luis ; Carvalho, Cristiane ; Pezon, Candido ; Rosenthal, Stephen P. ; La Rosa, Norman ; Vemuri, Nuripama ; Cherla, Gautam ; Nahar, Nilay. / Chronic kidney disease stages 3-5 and cardiovascular disease in the veterans affairs population. In: International Urology and Nephrology. 2009 ; Vol. 41, No. 2. pp. 443-451.
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AU - Ortega, Luis

AU - Carvalho, Cristiane

AU - Pezon, Candido

AU - Rosenthal, Stephen P.

AU - La Rosa, Norman

AU - Vemuri, Nuripama

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AU - Nahar, Nilay

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AB - Aim: Cardiovascular complications are common in patients with chronic kidney disease in the general population. The study aims to investigate the prevalence and prognosis of CKD stages 3-5 in the veterans affairs (VA) population, which is sicker with more co-morbid conditions. Methods: In this case-controlled study of 6,432 men the associations of risk factors with CKD and its risk of mortality were estimated using, primarily, logistic regression analysis. Results: The 1,045 (16.2%) patients with CKD stages 3-5 were older (72 ± 10 vs. 59 ± 13 years P < 0.0001) with more hypertension (53.6 vs. 39.6%, P < 0.0001), diabetes (24.9 vs. 19.8%, P < 0.0002), and CVD (35.3 vs. 17.8%, P < 0.0001) at baseline. Age ≤65 years (odds ratio [95% CI]) (4.95 [4.22-5.82]), hypertension (1.56 [1.34-1.79]), diabetes mellitus (1.21 [1.03-1.43]), CVD (1.71 [1.47-2.00]), and White not Hispanic (1.57 [1.32-1.85]) were independently associated with CKD. The prevalence of CVD at baseline increased with decreasing renal function. Old age (1.98 [1.66-2.35]), CKD (1.94 [1.61-2.33], CVD (1.46 [1.23-1.74]) and tobacco use (1.91 [1.05-3.47]) were independently associated with the 750 (11.7%) deaths. Conclusion: Among veterans, traditional cardiovascular risk factors, CVD, and CKD are highly prevalent. CKD is associated with increased risk of baseline CVD and follow-up mortality.

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