Abstract
It is increasingly clear that the long-term outcome of children with chronic kidney disease (CKD) is associated with their cardiovascular outcomes. Renal dysfunction affects cardiovascular outcomes, and cardiovascular dysfunction affects renal outcomes. Despite many publications about cardio-renal syndrome (CRS) types I to III (acute CRS, chronic CRS and acute renocardiac syndrome), the literature about type IV CRS (chronic renocardiac syndrome) remains scant. Here, we summarize the pathophysiological risk factors of cardiovascular comorbidity and CKD. We address the exceedingly high prevalence of cardiovascular morbidity and mortality in children and adolescents with CKD and their risk factors for cardiovascular disease (CVD). Of these risk factors, uremia, renal osteodystrophy, vitamin D pathophysiology, and Fibroblast Growth Factor 23 (FGF23)-related direct effects on the myocardium and the large vessels appear to be the most prominent. We identify potential targets for intervention and highlight the need for a multidisciplinary approach involving both pediatric cardiologists and nephrologists.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-95 |
| Number of pages | 7 |
| Journal | Progress in Pediatric Cardiology |
| Volume | 41 |
| DOIs | |
| State | Published - Jun 1 2016 |
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Keywords
- Cardiac Hypertrophy
- Chronic Kidney Disease
- Fibroblast Growth Factor 23
- Uremia
- Vitamin D
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pediatrics, Perinatology, and Child Health
Cite this
Chronic kidney disease and cardiac morbidity — What are the possible links? / Freundlich, Michael; Lipshultz, Steven E; Filler, Guido.
In: Progress in Pediatric Cardiology, Vol. 41, 01.06.2016, p. 89-95.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chronic kidney disease and cardiac morbidity — What are the possible links?
AU - Freundlich, Michael
AU - Lipshultz, Steven E
AU - Filler, Guido
PY - 2016/6/1
Y1 - 2016/6/1
N2 - It is increasingly clear that the long-term outcome of children with chronic kidney disease (CKD) is associated with their cardiovascular outcomes. Renal dysfunction affects cardiovascular outcomes, and cardiovascular dysfunction affects renal outcomes. Despite many publications about cardio-renal syndrome (CRS) types I to III (acute CRS, chronic CRS and acute renocardiac syndrome), the literature about type IV CRS (chronic renocardiac syndrome) remains scant. Here, we summarize the pathophysiological risk factors of cardiovascular comorbidity and CKD. We address the exceedingly high prevalence of cardiovascular morbidity and mortality in children and adolescents with CKD and their risk factors for cardiovascular disease (CVD). Of these risk factors, uremia, renal osteodystrophy, vitamin D pathophysiology, and Fibroblast Growth Factor 23 (FGF23)-related direct effects on the myocardium and the large vessels appear to be the most prominent. We identify potential targets for intervention and highlight the need for a multidisciplinary approach involving both pediatric cardiologists and nephrologists.
AB - It is increasingly clear that the long-term outcome of children with chronic kidney disease (CKD) is associated with their cardiovascular outcomes. Renal dysfunction affects cardiovascular outcomes, and cardiovascular dysfunction affects renal outcomes. Despite many publications about cardio-renal syndrome (CRS) types I to III (acute CRS, chronic CRS and acute renocardiac syndrome), the literature about type IV CRS (chronic renocardiac syndrome) remains scant. Here, we summarize the pathophysiological risk factors of cardiovascular comorbidity and CKD. We address the exceedingly high prevalence of cardiovascular morbidity and mortality in children and adolescents with CKD and their risk factors for cardiovascular disease (CVD). Of these risk factors, uremia, renal osteodystrophy, vitamin D pathophysiology, and Fibroblast Growth Factor 23 (FGF23)-related direct effects on the myocardium and the large vessels appear to be the most prominent. We identify potential targets for intervention and highlight the need for a multidisciplinary approach involving both pediatric cardiologists and nephrologists.
KW - Cardiac Hypertrophy
KW - Chronic Kidney Disease
KW - Fibroblast Growth Factor 23
KW - Uremia
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84977610670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84977610670&partnerID=8YFLogxK
U2 - 10.1016/j.ppedcard.2015.11.001
DO - 10.1016/j.ppedcard.2015.11.001
M3 - Review article
AN - SCOPUS:84977610670
VL - 41
SP - 89
EP - 95
JO - Progress in Pediatric Cardiology
JF - Progress in Pediatric Cardiology
SN - 1058-9813
ER -