Chronic hepatitis C and type II diabetes mellitus: A prospective cross-sectional study

Claudia O. Zein, Cynthia Levy, Ananda Basu, Nizar N. Zein

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

An epidemiologic link between chronic hepatitis C (HCV) and type II diabetes mellitus (DM) has been established. Our aims were to prospectively determine the prevalence of DM in interferon-naïve patients with HCV in comparison with the general population, and to determine the association between DM and impaired fasting glucose (IFG) with histological stage in patients with HCV. A consecutive sample of 179 patients was included in this prospective cross-sectional study. The crude percentage of DM for the cohort was 14.5%, different from the crude rate of 7.8% for the general population (p = 0.0008) and from the rate of 7.3% observed in a matched control group with non-HCV liver disease. The prevalence of DM and IFG (DM/IFG) was higher among HCV-infected patients with advanced versus those with early histological disease (p = 0.0004). Advanced histological disease predicted DM/IFG after controlling for other identified risk factors for DM. Family history was the only other independent predictor of DM/IFG in HCV-infected patients. In conclusion, patients with HCV had a higher prevalence of DM compared to the general population. The presence of advanced histological disease in genetically predisposed HCV-patients is associated with a higher prevalence of DM/IFG. DM and IFG were not associated with anthropomorphic markers of obesity in HCV patients, suggesting a unique multifactorial pathogenesis of DM in HCV.

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Type 2 Diabetes Mellitus
Diabetes Mellitus
Cross-Sectional Studies
Fasting
Glucose
Population
Interferons
Liver Diseases
Research Design
Obesity
Control Groups

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Chronic hepatitis C and type II diabetes mellitus : A prospective cross-sectional study. / Zein, Claudia O.; Levy, Cynthia; Basu, Ananda; Zein, Nizar N.

In: American Journal of Gastroenterology, Vol. 100, No. 1, 01.01.2005, p. 48-55.

Research output: Contribution to journalArticle

Zein, Claudia O. ; Levy, Cynthia ; Basu, Ananda ; Zein, Nizar N. / Chronic hepatitis C and type II diabetes mellitus : A prospective cross-sectional study. In: American Journal of Gastroenterology. 2005 ; Vol. 100, No. 1. pp. 48-55.
@article{17700953514f42c888dcc8e92c7da870,
title = "Chronic hepatitis C and type II diabetes mellitus: A prospective cross-sectional study",
abstract = "An epidemiologic link between chronic hepatitis C (HCV) and type II diabetes mellitus (DM) has been established. Our aims were to prospectively determine the prevalence of DM in interferon-na{\"i}ve patients with HCV in comparison with the general population, and to determine the association between DM and impaired fasting glucose (IFG) with histological stage in patients with HCV. A consecutive sample of 179 patients was included in this prospective cross-sectional study. The crude percentage of DM for the cohort was 14.5{\%}, different from the crude rate of 7.8{\%} for the general population (p = 0.0008) and from the rate of 7.3{\%} observed in a matched control group with non-HCV liver disease. The prevalence of DM and IFG (DM/IFG) was higher among HCV-infected patients with advanced versus those with early histological disease (p = 0.0004). Advanced histological disease predicted DM/IFG after controlling for other identified risk factors for DM. Family history was the only other independent predictor of DM/IFG in HCV-infected patients. In conclusion, patients with HCV had a higher prevalence of DM compared to the general population. The presence of advanced histological disease in genetically predisposed HCV-patients is associated with a higher prevalence of DM/IFG. DM and IFG were not associated with anthropomorphic markers of obesity in HCV patients, suggesting a unique multifactorial pathogenesis of DM in HCV.",
author = "Zein, {Claudia O.} and Cynthia Levy and Ananda Basu and Zein, {Nizar N.}",
year = "2005",
month = "1",
day = "1",
doi = "10.1111/j.1572-0241.2005.40429.x",
language = "English",
volume = "100",
pages = "48--55",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Chronic hepatitis C and type II diabetes mellitus

T2 - A prospective cross-sectional study

AU - Zein, Claudia O.

AU - Levy, Cynthia

AU - Basu, Ananda

AU - Zein, Nizar N.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - An epidemiologic link between chronic hepatitis C (HCV) and type II diabetes mellitus (DM) has been established. Our aims were to prospectively determine the prevalence of DM in interferon-naïve patients with HCV in comparison with the general population, and to determine the association between DM and impaired fasting glucose (IFG) with histological stage in patients with HCV. A consecutive sample of 179 patients was included in this prospective cross-sectional study. The crude percentage of DM for the cohort was 14.5%, different from the crude rate of 7.8% for the general population (p = 0.0008) and from the rate of 7.3% observed in a matched control group with non-HCV liver disease. The prevalence of DM and IFG (DM/IFG) was higher among HCV-infected patients with advanced versus those with early histological disease (p = 0.0004). Advanced histological disease predicted DM/IFG after controlling for other identified risk factors for DM. Family history was the only other independent predictor of DM/IFG in HCV-infected patients. In conclusion, patients with HCV had a higher prevalence of DM compared to the general population. The presence of advanced histological disease in genetically predisposed HCV-patients is associated with a higher prevalence of DM/IFG. DM and IFG were not associated with anthropomorphic markers of obesity in HCV patients, suggesting a unique multifactorial pathogenesis of DM in HCV.

AB - An epidemiologic link between chronic hepatitis C (HCV) and type II diabetes mellitus (DM) has been established. Our aims were to prospectively determine the prevalence of DM in interferon-naïve patients with HCV in comparison with the general population, and to determine the association between DM and impaired fasting glucose (IFG) with histological stage in patients with HCV. A consecutive sample of 179 patients was included in this prospective cross-sectional study. The crude percentage of DM for the cohort was 14.5%, different from the crude rate of 7.8% for the general population (p = 0.0008) and from the rate of 7.3% observed in a matched control group with non-HCV liver disease. The prevalence of DM and IFG (DM/IFG) was higher among HCV-infected patients with advanced versus those with early histological disease (p = 0.0004). Advanced histological disease predicted DM/IFG after controlling for other identified risk factors for DM. Family history was the only other independent predictor of DM/IFG in HCV-infected patients. In conclusion, patients with HCV had a higher prevalence of DM compared to the general population. The presence of advanced histological disease in genetically predisposed HCV-patients is associated with a higher prevalence of DM/IFG. DM and IFG were not associated with anthropomorphic markers of obesity in HCV patients, suggesting a unique multifactorial pathogenesis of DM in HCV.

UR - http://www.scopus.com/inward/record.url?scp=13744254182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13744254182&partnerID=8YFLogxK

U2 - 10.1111/j.1572-0241.2005.40429.x

DO - 10.1111/j.1572-0241.2005.40429.x

M3 - Article

C2 - 15654780

AN - SCOPUS:13744254182

VL - 100

SP - 48

EP - 55

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 1

ER -