Chronic glomerular microangiopathy and metastatic carcinoma

Dennis L. Laffay, Raymond R. Tubbs, Rafael Valenzuela, Phillip M. Hall, Lawrence J. McCormack

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Two patients with metastatic colonic adenocarcinoma developed deterioration of renal function six and nine months after the diagnosis of malignant disease. A renal biopsy specimen in one case and both postmortem specimens revealed thickening of glomerular capillary loops with focal reduplication of basement membrane-like material. Ultrastructural examination of all three specimens demonstrated a lucent subendothelial zone and no evidence of electron dense deposits. Antifibrinogen staining outlined most capillary loops in one case. It appears that chronic intravascular coagulation induced by the neoplasm was the major pathogenetic process involved in the production of the glomerular lesion in each case.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalHuman Pathology
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1979

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Carcinoma
Kidney
Basement Membrane
Adenocarcinoma
Electrons
Staining and Labeling
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Laffay, D. L., Tubbs, R. R., Valenzuela, R., Hall, P. M., & McCormack, L. J. (1979). Chronic glomerular microangiopathy and metastatic carcinoma. Human Pathology, 10(4), 433-438. https://doi.org/10.1016/S0046-8177(79)80049-0

Chronic glomerular microangiopathy and metastatic carcinoma. / Laffay, Dennis L.; Tubbs, Raymond R.; Valenzuela, Rafael; Hall, Phillip M.; McCormack, Lawrence J.

In: Human Pathology, Vol. 10, No. 4, 01.01.1979, p. 433-438.

Research output: Contribution to journalArticle

Laffay, DL, Tubbs, RR, Valenzuela, R, Hall, PM & McCormack, LJ 1979, 'Chronic glomerular microangiopathy and metastatic carcinoma', Human Pathology, vol. 10, no. 4, pp. 433-438. https://doi.org/10.1016/S0046-8177(79)80049-0
Laffay DL, Tubbs RR, Valenzuela R, Hall PM, McCormack LJ. Chronic glomerular microangiopathy and metastatic carcinoma. Human Pathology. 1979 Jan 1;10(4):433-438. https://doi.org/10.1016/S0046-8177(79)80049-0
Laffay, Dennis L. ; Tubbs, Raymond R. ; Valenzuela, Rafael ; Hall, Phillip M. ; McCormack, Lawrence J. / Chronic glomerular microangiopathy and metastatic carcinoma. In: Human Pathology. 1979 ; Vol. 10, No. 4. pp. 433-438.
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