Chronic fatigue syndrome

A working case definition

G. P. Holmes, J. E. Kaplan, N. M. Gantz, A. L. Komaroff, L. B. Schonberger, S. E. Straus, J. F. Jones, R. E. Dubois, C. Cunningham-Rundles, Savita G Pahwa, G. Tosato, L. S. Zegans, D. T. Purtilo, N. Brown, R. T. Schooley, I. Brus

Research output: Contribution to journalArticle

1302 Citations (Scopus)

Abstract

The chronic Epstein-Barr virus syndrome is a poorly defined symptom complex characterized primarily by chronic or recurrent debilitating fatigue and various combinations of other symptoms, including sore throat, lymph node pain and tenderness, headache, myalgia, and arthralgias. Although the syndrome has received recent attention, and has been diagnosed in many patients, the chronic Epstein-Barr virus syndrome has not been defined consistently. Despite the name of the syndrome, both the diagnostic value of Epstein-Barr virus serologic tests and the proposed causal relationship between Epstein-Barr virus infection and patients who have been diagnosed with the chronic Epstein-Barr virus syndrome remain doubtful. We propose a new name for the chronic Epstein-Barr virus syndrome - the chronic fatigue syndrome - that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue. We also present a working definition for the chronic fatigue syndrome designed to improve the comparability and reproducibility of clinical research and epidemiologic studies, and to provide a rational basis for evaluating patients who have chronic fatigue of undetermined cause.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalAnnals of Internal Medicine
Volume108
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

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Chronic Fatigue Syndrome
Human Herpesvirus 4
Fatigue
Names
Epstein-Barr Virus Infections
Pharyngitis
Myalgia
Arthralgia
Serologic Tests
Headache
Epidemiologic Studies
Lymph Nodes
Pain
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Holmes, G. P., Kaplan, J. E., Gantz, N. M., Komaroff, A. L., Schonberger, L. B., Straus, S. E., ... Brus, I. (1988). Chronic fatigue syndrome: A working case definition. Annals of Internal Medicine, 108(3), 387-389.

Chronic fatigue syndrome : A working case definition. / Holmes, G. P.; Kaplan, J. E.; Gantz, N. M.; Komaroff, A. L.; Schonberger, L. B.; Straus, S. E.; Jones, J. F.; Dubois, R. E.; Cunningham-Rundles, C.; Pahwa, Savita G; Tosato, G.; Zegans, L. S.; Purtilo, D. T.; Brown, N.; Schooley, R. T.; Brus, I.

In: Annals of Internal Medicine, Vol. 108, No. 3, 01.01.1988, p. 387-389.

Research output: Contribution to journalArticle

Holmes, GP, Kaplan, JE, Gantz, NM, Komaroff, AL, Schonberger, LB, Straus, SE, Jones, JF, Dubois, RE, Cunningham-Rundles, C, Pahwa, SG, Tosato, G, Zegans, LS, Purtilo, DT, Brown, N, Schooley, RT & Brus, I 1988, 'Chronic fatigue syndrome: A working case definition', Annals of Internal Medicine, vol. 108, no. 3, pp. 387-389.
Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE et al. Chronic fatigue syndrome: A working case definition. Annals of Internal Medicine. 1988 Jan 1;108(3):387-389.
Holmes, G. P. ; Kaplan, J. E. ; Gantz, N. M. ; Komaroff, A. L. ; Schonberger, L. B. ; Straus, S. E. ; Jones, J. F. ; Dubois, R. E. ; Cunningham-Rundles, C. ; Pahwa, Savita G ; Tosato, G. ; Zegans, L. S. ; Purtilo, D. T. ; Brown, N. ; Schooley, R. T. ; Brus, I. / Chronic fatigue syndrome : A working case definition. In: Annals of Internal Medicine. 1988 ; Vol. 108, No. 3. pp. 387-389.
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