Chronic ergot toxicity: A rare cause of lower extremity ischemia

George D. Garcia, James M. Goff, Neal C. Hadro, Sean D. O'Donnell, Patricia S. Greatorex

Research output: Contribution to journalArticle

33 Scopus citations


Chronic ergot toxicity is a rare cause of lower extremity ischemia. The cornerstone of therapy in ergot toxicity is to discontinue the use of caffeine, cigarettes, and all ergot-containing medications. Although multiple different therapies have been recommended for acute toxicity, no specific treatment is uniformly recommended in chronic toxicity. We present a case of long-term ergot use for migraine headaches in a woman who had severe chronic lower extremity claudication. This case demonstrates the unique features associated with the diagnosis and management of chronic ergot toxicity. We recommend a conservative approach consisting of observation, antiplatelet agents, and the discontinuance of ergots. If symptoms progress to rest pain or gangrene, surgical treatment should be considered.

Original languageEnglish (US)
Pages (from-to)1245-1247
Number of pages3
JournalJournal of vascular surgery
Issue number6
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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    Garcia, G. D., Goff, J. M., Hadro, N. C., O'Donnell, S. D., & Greatorex, P. S. (2000). Chronic ergot toxicity: A rare cause of lower extremity ischemia. Journal of vascular surgery, 31(6), 1245-1247.