Chronic epilepsy due to low grade temporal lobe tumors and due to hippocampal sclerosis: Do they differ in post-surgical outcome?

Prasad S S V Vannemreddy, Andres M Kanner, Michel C. Smith, Marvin Rossi, David Wallace, Siddharth N K Vannemreddy, Richard W. Byrne

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic seizures as a presenting feature of low grade temporal lobe gliomas and hippocampal sclerosis (HS) are reported to have similar outcomes although the prognostic indicators may not be the same. This study seeks to identify the variables that are associated with poor surgical outcome in both conditions. A retrospective analysis from our epilepsy data base was performed. All low-grade temporal lobe gliomas were selected and relevant variables were compared to the same variables in HS patients. There were 34 tumors (out of 233 cases of chronic temporal lobe epilepsy = 14.6 %) with a mean age of onset of 19 years, and the preoperative duration was 12.3 years. When compared to 120 HS patients both of these factors were significantly different (p < 0.001). Age at the time of surgery for tumors was 31.08 (p = 0.5). Tumors were left sided in 20 patients. In tumor cases amygdala resection was complete in 75 %, for hippocampus 24 % were complete and 39 % partial. Astrocytoma, ganglioglioma and oligodendroglioma constituted 80 % of tumor cases. Good outcome (Engel's Class I) was achieved in 88.2 % of tumor cases and 71 % of HS cases while poor outcome (Class III + IV) was seen in 5.9 and 16.7 % respectively. The follow up period for the two groups was not significantly different. In multivariate logistic regression analysis, the groups differed significantly in preoperative delay (between diagnosis and surgery) and in epilepsy outcome. Chronic temporal lobe epilepsy due to low-grade tumors had significantly better surgical outcome with considerably less preoperative delay. The age of onset of seizures was younger in HS patients but a delay in surgical treatment was significantly longer. Given that the diagnosis of treatment-resistant TLE secondary to HS can be established after two failed AED trials at optimal doses, shortening the interval between diagnosis and surgery may improve epilepsy outcome.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalJournal of Neuro-Oncology
Volume115
Issue number2
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Sclerosis
Temporal Lobe
Epilepsy
Neoplasms
Temporal Lobe Epilepsy
Age of Onset
Glioma
Seizures
Ganglioglioma
Oligodendroglioma
Astrocytoma
Amygdala
Hippocampus
Logistic Models
Regression Analysis
Databases
Therapeutics

Keywords

  • Epilepsy
  • Glioma
  • Hippocampal sclerosis
  • Outcome
  • Seizures
  • Temporal lobe
  • Tumors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Chronic epilepsy due to low grade temporal lobe tumors and due to hippocampal sclerosis : Do they differ in post-surgical outcome? / Vannemreddy, Prasad S S V; Kanner, Andres M; Smith, Michel C.; Rossi, Marvin; Wallace, David; Vannemreddy, Siddharth N K; Byrne, Richard W.

In: Journal of Neuro-Oncology, Vol. 115, No. 2, 2013, p. 225-231.

Research output: Contribution to journalArticle

Vannemreddy, Prasad S S V ; Kanner, Andres M ; Smith, Michel C. ; Rossi, Marvin ; Wallace, David ; Vannemreddy, Siddharth N K ; Byrne, Richard W. / Chronic epilepsy due to low grade temporal lobe tumors and due to hippocampal sclerosis : Do they differ in post-surgical outcome?. In: Journal of Neuro-Oncology. 2013 ; Vol. 115, No. 2. pp. 225-231.
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abstract = "Chronic seizures as a presenting feature of low grade temporal lobe gliomas and hippocampal sclerosis (HS) are reported to have similar outcomes although the prognostic indicators may not be the same. This study seeks to identify the variables that are associated with poor surgical outcome in both conditions. A retrospective analysis from our epilepsy data base was performed. All low-grade temporal lobe gliomas were selected and relevant variables were compared to the same variables in HS patients. There were 34 tumors (out of 233 cases of chronic temporal lobe epilepsy = 14.6 {\%}) with a mean age of onset of 19 years, and the preoperative duration was 12.3 years. When compared to 120 HS patients both of these factors were significantly different (p < 0.001). Age at the time of surgery for tumors was 31.08 (p = 0.5). Tumors were left sided in 20 patients. In tumor cases amygdala resection was complete in 75 {\%}, for hippocampus 24 {\%} were complete and 39 {\%} partial. Astrocytoma, ganglioglioma and oligodendroglioma constituted 80 {\%} of tumor cases. Good outcome (Engel's Class I) was achieved in 88.2 {\%} of tumor cases and 71 {\%} of HS cases while poor outcome (Class III + IV) was seen in 5.9 and 16.7 {\%} respectively. The follow up period for the two groups was not significantly different. In multivariate logistic regression analysis, the groups differed significantly in preoperative delay (between diagnosis and surgery) and in epilepsy outcome. Chronic temporal lobe epilepsy due to low-grade tumors had significantly better surgical outcome with considerably less preoperative delay. The age of onset of seizures was younger in HS patients but a delay in surgical treatment was significantly longer. Given that the diagnosis of treatment-resistant TLE secondary to HS can be established after two failed AED trials at optimal doses, shortening the interval between diagnosis and surgery may improve epilepsy outcome.",
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AU - Rossi, Marvin

AU - Wallace, David

AU - Vannemreddy, Siddharth N K

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