Chronic effects of carbamazepine on life-history strategies of Ceriodaphnia dubia in three successive generations

Kiran Lamichhane, Santos N. Garcia, Duane B. Huggett, Donald L. Deangelis, Thomas W. La Point

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Trace quantities of pharmaceuticals are continuously being discharged into the environment through domestic and industrial wastewater effluents, causing concern among scientists and regulators regarding potential long-term impacts on aquatic ecosystems. These compounds and their metabolites are constantly interacting with organisms at various life-cycle stages and may differentially influence the development of embryonic, larval, juvenile, and adult stages. To understand the possible cumulative effects of exposure to carbamazepine (CBZ), a multigenerational approach was taken in which survival, reproduction, respiration, growth, brood size, and biomass of Ceriodaphnia dubia were assessed at sublethal concentrations over the course of three successive generations. CBZ exposure significantly decreased fecundity at 196.7 μg/L in the F0 and F1 generations over 2 weeks and acclimatized at 264.6 μg/L in the F2 generation. Similarly, a significant decrease of neonate dry weight was observed at the 196.7 μg/L CBZ treatment in the F1 generation, and it acclimatized at 264.6 μg/L treatment level in the F2 generation. Median time to first brood release was significantly delayed at 264.6 μg/L in the F2 generation, indicating slower maturation. Results over three successive generations are not different than what one would obtain by testing simply the F0 generation. Furthermore, the effects measured were observed at concentrations two orders of magnitude higher than are environmentally relevant, and it is unlikely that CBZ poses a substantial risk to the environment regarding the end points measured in this study. However, additional research through laboratory and field multigenerational studies may be required to understand the overall risk of CBZ to other nontarget organisms.

Original languageEnglish
Pages (from-to)427-438
Number of pages12
JournalArchives of Environmental Contamination and Toxicology
Volume64
Issue number3
DOIs
StatePublished - Apr 1 2013

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Carbamazepine
Aquatic ecosystems
Metabolites
Drug products
Life cycle
Effluents
Biomass
Wastewater
Testing
Waste Water
Life Cycle Stages
Embryonic Development
Reproduction
Ecosystem
Fertility
Respiration
Life History Traits
Weights and Measures
Growth
Research

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Toxicology

Cite this

Chronic effects of carbamazepine on life-history strategies of Ceriodaphnia dubia in three successive generations. / Lamichhane, Kiran; Garcia, Santos N.; Huggett, Duane B.; Deangelis, Donald L.; La Point, Thomas W.

In: Archives of Environmental Contamination and Toxicology, Vol. 64, No. 3, 01.04.2013, p. 427-438.

Research output: Contribution to journalArticle

Lamichhane, Kiran ; Garcia, Santos N. ; Huggett, Duane B. ; Deangelis, Donald L. ; La Point, Thomas W. / Chronic effects of carbamazepine on life-history strategies of Ceriodaphnia dubia in three successive generations. In: Archives of Environmental Contamination and Toxicology. 2013 ; Vol. 64, No. 3. pp. 427-438.
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